PDF(Pubmed)
Abstract：
Engineered nanomaterials (ENMs) have been suggested as being capable of promoting inflammation, a key component in the pathways associated with carcinogenesis, cardiovascular disease, and other conditions. As a result, the risk assessment of biological markers as early-stage indicators has the potential to improve translation from experimental toxicologic findings to identifying evidence in human studies. The study aims to review the possible early biological changes in workers exposed to carbon black (CB), followed by an evidentiary quality evaluation to determine the predictive value of the biological markers.
We conducted a literature search to identify epidemiological studies that assessed biological markers that were involved in the inflammatory process at early stages among workers with exposure to CB. We reviewed the studies with specific reference to the study design, statistical analyses, findings, and limitations.
We identified five Chinese studies that investigated the potential impact of exposure to CB on inflammatory markers, bronchial wall thickening, genomic instability, and lung function impairment in CB production workers. Of the five Chinese studies, four were cross-sectional; another study reported results at two-time points over six years of follow-up. The authors of all five studies concluded positive relationships between exposure and the inflammatory cytokine profiles. The weak to very weak correlations between biomarkers and early-stage endpoints were reported.
Most inflammatory markers failed to satisfy the proposed evidentiary quality criteria. The significance of the results of the reviewed studies is limited by the cross-sectional study design, inconsistency in results, uncertain clinical relevance, and high occupational exposures. Based on this review, the risk assessment relying on inflammatory markers does not seem appropriate at this time. Nevertheless, the novel research warrants further exploration in assessing exposure to ENMs and corresponding potential health risks in occupational settings.
We conducted a literature search to identify epidemiological studies that assessed biological markers that were involved in the inflammatory process at early stages among workers with exposure to CB. We reviewed the studies with specific reference to the study design, statistical analyses, findings, and limitations.
We identified five Chinese studies that investigated the potential impact of exposure to CB on inflammatory markers, bronchial wall thickening, genomic instability, and lung function impairment in CB production workers. Of the five Chinese studies, four were cross-sectional; another study reported results at two-time points over six years of follow-up. The authors of all five studies concluded positive relationships between exposure and the inflammatory cytokine profiles. The weak to very weak correlations between biomarkers and early-stage endpoints were reported.
Most inflammatory markers failed to satisfy the proposed evidentiary quality criteria. The significance of the results of the reviewed studies is limited by the cross-sectional study design, inconsistency in results, uncertain clinical relevance, and high occupational exposures. Based on this review, the risk assessment relying on inflammatory markers does not seem appropriate at this time. Nevertheless, the novel research warrants further exploration in assessing exposure to ENMs and corresponding potential health risks in occupational settings.
摘要：
■工程纳米材料（ENM）已被认为能够促进炎症，与致癌相关的途径中的一个关键组成部分，心血管疾病,和其他条件。因此,生物标志物作为早期指标的风险评估有可能改善人体研究中从实验毒理学发现到确定证据的转化.该研究旨在回顾接触炭黑（CB）的工人可能的早期生物学变化，然后进行证据质量评估，以确定生物标志物的预测价值。
■我们进行了文献检索，以确定流行病学研究，该研究评估了在接触CB的工人中早期参与炎症过程的生物学标志物。我们回顾了这些研究，具体参考了研究设计，统计分析，调查结果,和限制。
■我们确定了五项中国研究，调查了暴露于CB对炎症标志物的潜在影响，支气管壁增厚，基因组不稳定性，CB生产工人的肺功能损害。在五个中国研究中，4项是横断面的;另一项研究报告了在6年随访的两个时间点的结果.所有五项研究的作者都得出结论，暴露与炎性细胞因子谱之间存在正相关关系。报告了生物标志物与早期终点之间的弱至非常弱的相关性。
■大多数炎症标记物未能满足提出的证据质量标准。综述研究结果的意义受到横断面研究设计的限制，结果不一致，不确定的临床相关性，和高职业暴露。基于这篇综述,目前依赖炎症标志物的风险评估似乎不合适.然而，这项新的研究需要在评估职业环境中ENM暴露和相应的潜在健康风险方面进行进一步的探索.
■我们进行了文献检索，以确定流行病学研究，该研究评估了在接触CB的工人中早期参与炎症过程的生物学标志物。我们回顾了这些研究，具体参考了研究设计，统计分析，调查结果,和限制。
■我们确定了五项中国研究，调查了暴露于CB对炎症标志物的潜在影响，支气管壁增厚，基因组不稳定性，CB生产工人的肺功能损害。在五个中国研究中，4项是横断面的;另一项研究报告了在6年随访的两个时间点的结果.所有五项研究的作者都得出结论，暴露与炎性细胞因子谱之间存在正相关关系。报告了生物标志物与早期终点之间的弱至非常弱的相关性。
■大多数炎症标记物未能满足提出的证据质量标准。综述研究结果的意义受到横断面研究设计的限制，结果不一致，不确定的临床相关性，和高职业暴露。基于这篇综述,目前依赖炎症标志物的风险评估似乎不合适.然而，这项新的研究需要在评估职业环境中ENM暴露和相应的潜在健康风险方面进行进一步的探索.
