PDF(Pubmed)
Abstract：
BACKGROUND: Mycophenolate mofetil (MMF) is an immunosuppressive drug that is frequently prescribed to patients with rheumatological diseases. MMF\'s side effects include abdominal discomfort, nausea, vomiting, and other gastro-intestinal side effects, which typically appear in the first few months of treatment. However, late-onset diarrhea does not rule out the presence of MMF-induced colitis, which can be misdiagnosed since it is linked to a broad range of histopathological characteristics, including alterations that resemble inflammatory bowel disease, graft-versus-host disease, and ischemia. The differences in treatment response may be explained by the complexity of the histopathologic characteristics.
METHODS: Here we present a case of a 29-year-old Arabian female with lupus nephritis who started on MMF as induction therapy. In two months, the patient was presented to the Emergency Department with diarrhea and manifestations of severe dehydration. Infectious diseases and adverse drug events were suspected, so the patient was admitted for further workup, and MMF was stopped. The patient was diagnosed with MMF-induced colitis based on colonoscopy and histological findings. Fourteen days after stopping MMF, she was within her baseline.
CONCLUSIONS: The purpose of this paper is to report a case of early-onset MMF-induced colitis in a patient with lupus nephritis who had started MMF as induction therapy. A review of the available literature on this uncommon immunosuppressive effect is also presented.
METHODS: Here we present a case of a 29-year-old Arabian female with lupus nephritis who started on MMF as induction therapy. In two months, the patient was presented to the Emergency Department with diarrhea and manifestations of severe dehydration. Infectious diseases and adverse drug events were suspected, so the patient was admitted for further workup, and MMF was stopped. The patient was diagnosed with MMF-induced colitis based on colonoscopy and histological findings. Fourteen days after stopping MMF, she was within her baseline.
CONCLUSIONS: The purpose of this paper is to report a case of early-onset MMF-induced colitis in a patient with lupus nephritis who had started MMF as induction therapy. A review of the available literature on this uncommon immunosuppressive effect is also presented.
摘要：
背景：霉酚酸酯（MMF）是一种免疫抑制药物，常用于风湿性疾病患者。MMF的副作用包括腹部不适，恶心,呕吐,和其他胃肠道副作用，通常出现在治疗的头几个月。然而,迟发性腹泻不排除MMF诱导的结肠炎的存在，这可能会被误诊，因为它与广泛的组织病理学特征有关，包括类似炎症性肠病的改变，移植物抗宿主病,和缺血。治疗反应的差异可以通过组织病理学特征的复杂性来解释。
方法：这里我们介绍一例29岁的阿拉伯女性狼疮性肾炎患者，开始使用MMF作为诱导治疗。两个月后,患者因腹泻和严重脱水的表现被送往急诊科。怀疑有传染病和药物不良事件,所以病人入院接受进一步的检查,MMF被阻止了。根据结肠镜检查和组织学发现，该患者被诊断为MMF诱导的结肠炎。停止MMF14天后，她在基线之内.
结论：本文的目的是报告1例狼疮性肾炎患者开始MMF作为诱导治疗的早发性MMF诱导结肠炎。还介绍了有关这种罕见的免疫抑制作用的现有文献的综述。
方法：这里我们介绍一例29岁的阿拉伯女性狼疮性肾炎患者，开始使用MMF作为诱导治疗。两个月后,患者因腹泻和严重脱水的表现被送往急诊科。怀疑有传染病和药物不良事件,所以病人入院接受进一步的检查,MMF被阻止了。根据结肠镜检查和组织学发现，该患者被诊断为MMF诱导的结肠炎。停止MMF14天后，她在基线之内.
结论：本文的目的是报告1例狼疮性肾炎患者开始MMF作为诱导治疗的早发性MMF诱导结肠炎。还介绍了有关这种罕见的免疫抑制作用的现有文献的综述。
