PDF(Pubmed)
Abstract：
BACKGROUND: Blood pressure is a vital hemodynamic marker during the neonatal period. However, normative values are often derived from small observational studies. Understanding the normative range would help to identify ideal thresholds for intervention to treat hypotension or hypertension. Therefore, the aim of this study was to assess observed blood pressure values in neonates who have not received any blood-pressure modifying treatments from birth to three months postnatal age and whether these vary according to birth weight, gestational age and postnatal age.
METHODS: This was a systematic review. A literature search was conducted in MEDLINE, PubMed, Embase, Cochrane Library, and CINAHL from 1946 to 2017 on blood pressure in neonates from birth to 3 months of age (PROSPERO ID CRD42018092886). Unpublished data were included where appropriate.
RESULTS: Of 3,587 non-duplicate publications identified, 30 were included (one unpublished study). Twelve studies contained data grouped by birth weight, while 23 contained data grouped by gestational age. Study and clinical heterogeneity precluded meta-analyses thus results are presented by subgroup. A consistent blood pressure rise was associated with increasing birth weight, gestational age, and postnatal age. In addition, blood pressure seemed to rise more rapidly in the most preterm and low birth weight neonates.
CONCLUSIONS: Despite blood pressure increasing with birth weight, gestational age, and postnatal age, there was marked blood pressure variability observed throughout. To better define hypotension and hypertension, future studies should develop consistent approaches for factors related to blood pressure variability, including the method and timing of measurement as well as statistical control of relevant patient characteristics.
METHODS: This was a systematic review. A literature search was conducted in MEDLINE, PubMed, Embase, Cochrane Library, and CINAHL from 1946 to 2017 on blood pressure in neonates from birth to 3 months of age (PROSPERO ID CRD42018092886). Unpublished data were included where appropriate.
RESULTS: Of 3,587 non-duplicate publications identified, 30 were included (one unpublished study). Twelve studies contained data grouped by birth weight, while 23 contained data grouped by gestational age. Study and clinical heterogeneity precluded meta-analyses thus results are presented by subgroup. A consistent blood pressure rise was associated with increasing birth weight, gestational age, and postnatal age. In addition, blood pressure seemed to rise more rapidly in the most preterm and low birth weight neonates.
CONCLUSIONS: Despite blood pressure increasing with birth weight, gestational age, and postnatal age, there was marked blood pressure variability observed throughout. To better define hypotension and hypertension, future studies should develop consistent approaches for factors related to blood pressure variability, including the method and timing of measurement as well as statistical control of relevant patient characteristics.
摘要：
背景：在新生儿期，血压是一个重要的血流动力学指标。然而,规范值通常来自小型观察性研究。了解规范范围将有助于确定干预治疗低血压或高血压的理想阈值。因此,这项研究的目的是评估从出生到出生后三个月没有接受任何血压调节治疗的新生儿的观察到的血压值，以及这些值是否根据出生体重而变化，胎龄和产后年龄。
方法：这是一个系统综述。在MEDLINE进行了文献检索，PubMed,Embase,科克伦图书馆,1946年至2017年CINAHL对出生至3月龄新生儿血压的影响(PROSPEROIDCRD42018092886)。适当时包括未公布的数据。
结果：在确定的3,587个非重复出版物中，包括30项（一项未发表的研究）。12项研究包含按出生体重分组的数据，而23则包含按胎龄分组的数据。研究和临床异质性排除了荟萃分析，因此结果按亚组表示。持续的血压升高与出生体重的增加有关，胎龄,和产后年龄。此外,大多数早产和低出生体重新生儿的血压似乎上升得更快。
结论：尽管血压随着出生体重的增加而增加，胎龄,和出生后的年龄，自始至终观察到明显的血压变异性.为了更好地定义低血压和高血压，未来的研究应该为与血压变异性相关的因素开发一致的方法，包括测量方法和时间以及相关患者特征的统计控制。
方法：这是一个系统综述。在MEDLINE进行了文献检索，PubMed,Embase,科克伦图书馆,1946年至2017年CINAHL对出生至3月龄新生儿血压的影响(PROSPEROIDCRD42018092886)。适当时包括未公布的数据。
结果：在确定的3,587个非重复出版物中，包括30项（一项未发表的研究）。12项研究包含按出生体重分组的数据，而23则包含按胎龄分组的数据。研究和临床异质性排除了荟萃分析，因此结果按亚组表示。持续的血压升高与出生体重的增加有关，胎龄,和产后年龄。此外,大多数早产和低出生体重新生儿的血压似乎上升得更快。
结论：尽管血压随着出生体重的增加而增加，胎龄,和出生后的年龄，自始至终观察到明显的血压变异性.为了更好地定义低血压和高血压，未来的研究应该为与血压变异性相关的因素开发一致的方法，包括测量方法和时间以及相关患者特征的统计控制。
