PDF(Pubmed)
Abstract：
BACKGROUND: Growing up with parental alcohol use disorder (AUD) is a risk factor for psychiatric disorders. This study investigated the risk of mood disorders and of anxiety disorders in the adult children of parents with AUD, adjusted for sociodemographic factors.
METHODS: Individual-level register data on the total population were linked to follow children of parents with AUD from 1973 to 2018 to assess their risk of mood disorders and of anxiety disorders. AUD, mood disorders and anxiety disorders were defined with International Statistical Classification of Diseases and Related Health Problems codes from the National Patient Register. HRs of outcomes were calculated with Cox regression. Model 1 was adjusted for the child\'s sex, parental education and death of a parent. Model 2 was adjusted for those factors and parental diagnosis of mood or anxiety disorder.
RESULTS: Those with ≥1 parent with AUD (99 723 of 2 421 479 children) had a higher risk of mood disorder and of anxiety disorder than those whose parents did not have AUD (HR mood 2.32, 95% CI 2.26 to 2.39; HR anxiety 2.66, 95% CI 2.60 to 2.72). The risk remained elevated after adjustment for sociodemographic factors and parental psychiatric diagnosis (HR mood 1.67, 95% CI 1.63 to 1.72; HR anxiety 1.74, 95% CI 1.69 to 1.78). The highest risks were associated with AUD in both parents, followed by AUD in mothers and then in fathers.
CONCLUSIONS: Adult children of parents with AUD have a raised risk of mood and anxiety disorders even after adjustment for sociodemographic factors and parental mood or anxiety disorder. These population-level findings can inform future policies and interventions.
METHODS: Individual-level register data on the total population were linked to follow children of parents with AUD from 1973 to 2018 to assess their risk of mood disorders and of anxiety disorders. AUD, mood disorders and anxiety disorders were defined with International Statistical Classification of Diseases and Related Health Problems codes from the National Patient Register. HRs of outcomes were calculated with Cox regression. Model 1 was adjusted for the child\'s sex, parental education and death of a parent. Model 2 was adjusted for those factors and parental diagnosis of mood or anxiety disorder.
RESULTS: Those with ≥1 parent with AUD (99 723 of 2 421 479 children) had a higher risk of mood disorder and of anxiety disorder than those whose parents did not have AUD (HR mood 2.32, 95% CI 2.26 to 2.39; HR anxiety 2.66, 95% CI 2.60 to 2.72). The risk remained elevated after adjustment for sociodemographic factors and parental psychiatric diagnosis (HR mood 1.67, 95% CI 1.63 to 1.72; HR anxiety 1.74, 95% CI 1.69 to 1.78). The highest risks were associated with AUD in both parents, followed by AUD in mothers and then in fathers.
CONCLUSIONS: Adult children of parents with AUD have a raised risk of mood and anxiety disorders even after adjustment for sociodemographic factors and parental mood or anxiety disorder. These population-level findings can inform future policies and interventions.
摘要：
背景：与父母饮酒障碍（AUD）一起成长是精神疾病的危险因素。这项研究调查了患有AUD的父母的成年子女的情绪障碍和焦虑障碍的风险，根据社会人口因素进行调整。
方法：将总人口的个人层面登记数据与1973年至2018年AUD父母子女的随访数据相关联，以评估他们患情绪障碍和焦虑症的风险。AUD,心境障碍和焦虑障碍根据国家患者登记册中的疾病和相关健康问题国际统计分类代码进行定义.用Cox回归计算结果的HR。模型1根据孩子的性别进行了调整，父母的教育和父母的死亡。模型2针对这些因素和父母对情绪或焦虑障碍的诊断进行了调整。
结果：与父母没有AUD的人相比，父母≥1名AUD的人（2421479名儿童中的99723名）患情绪障碍和焦虑症的风险更高（HR情绪2.32，95％CI2.26至2.39；HR焦虑2.66，95％CI2.60至2.72）。调整社会人口统计学因素和父母精神病诊断后，风险仍然升高（HR情绪1.67，95％CI1.63至1.72；HR焦虑1.74，95％CI1.69至1.78）。在父母双方中，最高的风险与AUD相关，其次是AUD在母亲和父亲。
结论：父母患有AUD的成年子女即使在调整社会人口统计学因素和父母的情绪或焦虑障碍后，患情绪和焦虑障碍的风险也会增加。这些人口层面的调查结果可以为未来的政策和干预提供信息。
方法：将总人口的个人层面登记数据与1973年至2018年AUD父母子女的随访数据相关联，以评估他们患情绪障碍和焦虑症的风险。AUD,心境障碍和焦虑障碍根据国家患者登记册中的疾病和相关健康问题国际统计分类代码进行定义.用Cox回归计算结果的HR。模型1根据孩子的性别进行了调整，父母的教育和父母的死亡。模型2针对这些因素和父母对情绪或焦虑障碍的诊断进行了调整。
结果：与父母没有AUD的人相比，父母≥1名AUD的人（2421479名儿童中的99723名）患情绪障碍和焦虑症的风险更高（HR情绪2.32，95％CI2.26至2.39；HR焦虑2.66，95％CI2.60至2.72）。调整社会人口统计学因素和父母精神病诊断后，风险仍然升高（HR情绪1.67，95％CI1.63至1.72；HR焦虑1.74，95％CI1.69至1.78）。在父母双方中，最高的风险与AUD相关，其次是AUD在母亲和父亲。
结论：父母患有AUD的成年子女即使在调整社会人口统计学因素和父母的情绪或焦虑障碍后，患情绪和焦虑障碍的风险也会增加。这些人口层面的调查结果可以为未来的政策和干预提供信息。
