PDF(Pubmed)
Abstract：
UNASSIGNED: Collagen triple helix repeat containing 1 (CTHRC1) is a protein that has been implicated in pro-migratory pathways, arterial tissue-repair processes, and inhibition of collagen deposition via the regulation of multiple signaling cascades. Studies have also demonstrated an upregulation of CTHRC1 in multiple cancers where it has been linked to enhanced proliferation, invasion, and metastasis. However, the understanding of the exact role and mechanisms of CTHRC1 in cancer is far from complete.
UNASSIGNED: This review focuses on analyzing the role of CTHRC1 in cancer as well as its associations with clinicopathologies and cancer-related processes and signaling. We have also summarized the available literature information regarding the role of CTHRC1 in tumor microenvironment and immune signaling. Finally, we have discussed the mechanisms associated with CTHRC1 regulations, and opportunities and challenges regarding the development of CTHRC1 as a potential target for cancer management.
UNASSIGNED: CTHRC1 is a multifaceted protein with critical roles in cancer progression and other pathological conditions. Its association with lower overall survival in various cancers, and impact on the tumor immune microenvironment make it an intriguing target for further research and potential therapeutic interventions in cancer.
UNASSIGNED: This review focuses on analyzing the role of CTHRC1 in cancer as well as its associations with clinicopathologies and cancer-related processes and signaling. We have also summarized the available literature information regarding the role of CTHRC1 in tumor microenvironment and immune signaling. Finally, we have discussed the mechanisms associated with CTHRC1 regulations, and opportunities and challenges regarding the development of CTHRC1 as a potential target for cancer management.
UNASSIGNED: CTHRC1 is a multifaceted protein with critical roles in cancer progression and other pathological conditions. Its association with lower overall survival in various cancers, and impact on the tumor immune microenvironment make it an intriguing target for further research and potential therapeutic interventions in cancer.
摘要：
■含有1的胶原三螺旋重复序列（CTHRC1）是一种与促迁移途径有关的蛋白质，动脉组织修复过程，并通过调节多个信号级联来抑制胶原沉积。研究还表明，在多种癌症中，CTHRC1的上调与增殖增强有关，入侵,和转移。然而,对CTHRC1在癌症中的确切作用和机制的理解还很远。
■这篇综述的重点是分析CTHRC1在癌症中的作用及其与临床病理和癌症相关过程和信号传导的关系。我们还总结了有关CTHRC1在肿瘤微环境和免疫信号传导中的作用的现有文献信息。最后,我们已经讨论了与CTHRC1法规相关的机制，以及将CTHRC1发展为癌症管理的潜在目标的机遇和挑战。
■CTHRC1是一种多方面的蛋白质，在癌症进展和其他病理状况中具有关键作用。它与各种癌症的总体生存率降低有关，以及对肿瘤免疫微环境的影响使其成为癌症进一步研究和潜在治疗干预的有趣目标。
■这篇综述的重点是分析CTHRC1在癌症中的作用及其与临床病理和癌症相关过程和信号传导的关系。我们还总结了有关CTHRC1在肿瘤微环境和免疫信号传导中的作用的现有文献信息。最后,我们已经讨论了与CTHRC1法规相关的机制，以及将CTHRC1发展为癌症管理的潜在目标的机遇和挑战。
■CTHRC1是一种多方面的蛋白质，在癌症进展和其他病理状况中具有关键作用。它与各种癌症的总体生存率降低有关，以及对肿瘤免疫微环境的影响使其成为癌症进一步研究和潜在治疗干预的有趣目标。
