Abstract：
UNASSIGNED: Olfactory dysfunction is a common COVID-19 symptom, posing treatment challenges.
UNASSIGNED: We aimed to investigate the efficacy of frequency-controlled ear acupuncture in treating COVID-19-related olfactory dysfunction.
UNASSIGNED: A randomized, participant-blind clinical trial occurred at the Rasoul Akram Hospital (IRCT20210311050671N1). Forty patients were recruited, and 20 patients were randomly assigned to either the experimental or control group. The primary outcome was the improvement in patients\' quality of smell. The olfactory dysfunction was confirmed using the Smell Identification Test. The intervention group received two sessions of acupuncture treatment according to auricular frequency treatment, with a one-week interval, while the control group received an equal number of switched-off laser sessions. Both groups were instructed to use nasal betamethasone drops. The patients were asked to rank their ability to smell before and after each intervention on a 10-point visual analog scale. Secondary outcomes were related side effects.
UNASSIGNED: Covariance analysis revealed a significant difference in adjusted scores between the groups (F [37, 1] = 37.463; p = 0.000, Eta2 = 0.503). The smell quality improved from 2.80 ± 1.76 to 5.22 ± 3.40 after treatment in the intervention group (p = 0.007), while the control group showed no significant change (p = 0.184). Three patients reported short and transient side effects, such as nausea, headache, and dizziness, in the first hours after the intervention.
UNASSIGNED: Frequency-controlled ear acupuncture is an effective option for treating COVID-19-related olfactory dysfunction. The study highlights the potential of alternative therapies in the treatment of this condition, and further research is warranted to investigate its long-term effects.
UNASSIGNED: We aimed to investigate the efficacy of frequency-controlled ear acupuncture in treating COVID-19-related olfactory dysfunction.
UNASSIGNED: A randomized, participant-blind clinical trial occurred at the Rasoul Akram Hospital (IRCT20210311050671N1). Forty patients were recruited, and 20 patients were randomly assigned to either the experimental or control group. The primary outcome was the improvement in patients\' quality of smell. The olfactory dysfunction was confirmed using the Smell Identification Test. The intervention group received two sessions of acupuncture treatment according to auricular frequency treatment, with a one-week interval, while the control group received an equal number of switched-off laser sessions. Both groups were instructed to use nasal betamethasone drops. The patients were asked to rank their ability to smell before and after each intervention on a 10-point visual analog scale. Secondary outcomes were related side effects.
UNASSIGNED: Covariance analysis revealed a significant difference in adjusted scores between the groups (F [37, 1] = 37.463; p = 0.000, Eta2 = 0.503). The smell quality improved from 2.80 ± 1.76 to 5.22 ± 3.40 after treatment in the intervention group (p = 0.007), while the control group showed no significant change (p = 0.184). Three patients reported short and transient side effects, such as nausea, headache, and dizziness, in the first hours after the intervention.
UNASSIGNED: Frequency-controlled ear acupuncture is an effective option for treating COVID-19-related olfactory dysfunction. The study highlights the potential of alternative therapies in the treatment of this condition, and further research is warranted to investigate its long-term effects.
摘要：
■嗅觉功能障碍是一种常见的COVID-19症状，带来治疗挑战。
■我们旨在研究频率控制耳针治疗COVID-19相关嗅觉功能障碍的疗效。
■随机，参与者盲临床试验在RasoulAkram医院进行(IRCT20210311050671N1).招募了40名患者，20例患者被随机分配到实验组或对照组.主要结果是患者嗅觉质量的改善。使用气味鉴定测试确认嗅觉功能障碍。干预组采用耳频针刺治疗2次,间隔一周，而对照组则接收了相同数量的关闭激光会话。指示两组使用鼻给他米松滴剂。要求患者在每次干预前后以10点视觉模拟量表对其嗅觉能力进行排名。次要结果是相关的副作用。
■协方差分析显示，两组之间的调整分数存在显着差异（F[37，1]=37.463；p=0.000，Eta2=0.503）。干预组治疗后嗅觉质量从2.80±1.76改善为5.22±3.40(p=0.007),对照组无明显变化(p=0.184)。三名患者报告了短暂和短暂的副作用，比如恶心，头痛,头晕,在干预后的头几个小时。
■频率控制耳针是治疗COVID-19相关嗅觉功能障碍的有效选择。该研究强调了替代疗法在治疗这种疾病方面的潜力，并且需要进一步的研究来调查其长期影响。
■我们旨在研究频率控制耳针治疗COVID-19相关嗅觉功能障碍的疗效。
■随机，参与者盲临床试验在RasoulAkram医院进行(IRCT20210311050671N1).招募了40名患者，20例患者被随机分配到实验组或对照组.主要结果是患者嗅觉质量的改善。使用气味鉴定测试确认嗅觉功能障碍。干预组采用耳频针刺治疗2次,间隔一周，而对照组则接收了相同数量的关闭激光会话。指示两组使用鼻给他米松滴剂。要求患者在每次干预前后以10点视觉模拟量表对其嗅觉能力进行排名。次要结果是相关的副作用。
■协方差分析显示，两组之间的调整分数存在显着差异（F[37，1]=37.463；p=0.000，Eta2=0.503）。干预组治疗后嗅觉质量从2.80±1.76改善为5.22±3.40(p=0.007),对照组无明显变化(p=0.184)。三名患者报告了短暂和短暂的副作用，比如恶心，头痛,头晕,在干预后的头几个小时。
■频率控制耳针是治疗COVID-19相关嗅觉功能障碍的有效选择。该研究强调了替代疗法在治疗这种疾病方面的潜力，并且需要进一步的研究来调查其长期影响。
