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Abstract：
Flexible high-density microelectrode arrays (HDMEAs) are emerging as a key component in closed-loop brain-machine interfaces (BMIs), providing high-resolution functionality for recording, stimulation, or both. The flexibility of these arrays provides advantages over rigid ones, such as reduced mismatch between interface and tissue, resilience to micromotion, and sustained long-term performance. This review summarizes the recent developments and applications of flexible HDMEAs in closed-loop BMI systems. It delves into the various challenges encountered in the development of ideal flexible HDMEAs for closed-loop BMI systems and highlights the latest methodologies and breakthroughs to address these challenges. These insights could be instrumental in guiding the creation of future generations of flexible HDMEAs, specifically tailored for use in closed-loop BMIs. The review thoroughly explores both the current state and prospects of these advanced arrays, emphasizing their potential in enhancing BMI technology.
摘要：
柔性高密度微电极阵列（HDMEA）正在成为闭环脑机接口（BMI）的关键组件，提供高分辨率录制功能，刺激,或者两者兼而有之。这些阵列的灵活性提供了优于刚性阵列的优势，例如减少界面和组织之间的不匹配，对微动的弹性，和持续的长期业绩。本文综述了柔性HDMEA在闭环BMI系统中的最新发展和应用。它深入研究了在为闭环BMI系统开发理想的灵活HDMEA时遇到的各种挑战，并强调了解决这些挑战的最新方法和突破。这些见解可能有助于指导未来几代灵活的HDMEA的创建，专门用于闭环BMI。这篇综述彻底探讨了这些先进阵列的现状和前景，强调他们在增强BMI技术方面的潜力。
