PDF(Pubmed)
Abstract：
UNASSIGNED: The objective was to analyze the impact of the uterine artery pulsatility index (PI) on pregnancy outcomes by measuring uterine artery blood flow on the day of endometrial transformation in patients undergoing frozen-thawed embryo transfer (FET).
UNASSIGNED: This was a case-control study. In total, 2,036 patients who underwent FET at the Third Affiliated Hospital of Zhengzhou University from October 2019 to September 2020 were included. The patients were divided into a clinical pregnancy group and a nonclinical pregnancy group according to pregnancy outcome. A multivariate logistic regression model was used to analyze the factors affecting the clinical pregnancy rate. The receiver operating characteristic (ROC) curve was used to determine the optimal mean PI cutoff value of 1.75. After 1:1 propensity score matching (PSM), 562 patients were included. For statistical description and analysis, the patients were divided into two groups: a group with a mean PI > 1.75 and a group with a mean PI ≤ 1.75.
UNASSIGNED: The clinical pregnancy group included 1,218 cycles, and the nonclinical pregnancy group included 818 cycles. There were significant differences in female age (P<0.01), infertility type (P=0.04), baseline follicle-stimulating hormone level (P=0.04), anti-Müllerian hormone (AMH) level (P<0.01), antral follicle count (P<0.01), number of transferred embryos (P=0.045) and type of transferred embryo (P<0.01). There was no significant difference in the mean bilateral PI (1.98 ± 0.34 vs. 1.95 ± 0.35, P=0.10). The multivariate analysis results showed that maternal age (AOR=0.95, 95% CI=0.93-0.98, P<0.01), AMH level (AOR=1.00, 95% CI=1.00-1.01, P=0.045), number of transferred embryos (AOR=1.98, 95% CI=1.47-2.70, P<0.01), and type of transferred embryo (AOR=3.10, 95% CI=2.27-4.23, P<0.01) were independent factors influencing the clinical pregnancy rate. The mean PI (AOR=0.85, 95% CI=0.70-1.05; P=0.13) was not an independent factor influencing the clinical pregnancy rate. Participants were divided into two groups according to the mean PI cutoff value of 1.75, and there was no significant difference between the two groups (P > 0.05).
UNASSIGNED: In this study, we found that the uterine artery PI on the day of endometrial transformation in patients undergoing FET is not a good predictor of pregnancy outcomes.
UNASSIGNED: This was a case-control study. In total, 2,036 patients who underwent FET at the Third Affiliated Hospital of Zhengzhou University from October 2019 to September 2020 were included. The patients were divided into a clinical pregnancy group and a nonclinical pregnancy group according to pregnancy outcome. A multivariate logistic regression model was used to analyze the factors affecting the clinical pregnancy rate. The receiver operating characteristic (ROC) curve was used to determine the optimal mean PI cutoff value of 1.75. After 1:1 propensity score matching (PSM), 562 patients were included. For statistical description and analysis, the patients were divided into two groups: a group with a mean PI > 1.75 and a group with a mean PI ≤ 1.75.
UNASSIGNED: The clinical pregnancy group included 1,218 cycles, and the nonclinical pregnancy group included 818 cycles. There were significant differences in female age (P<0.01), infertility type (P=0.04), baseline follicle-stimulating hormone level (P=0.04), anti-Müllerian hormone (AMH) level (P<0.01), antral follicle count (P<0.01), number of transferred embryos (P=0.045) and type of transferred embryo (P<0.01). There was no significant difference in the mean bilateral PI (1.98 ± 0.34 vs. 1.95 ± 0.35, P=0.10). The multivariate analysis results showed that maternal age (AOR=0.95, 95% CI=0.93-0.98, P<0.01), AMH level (AOR=1.00, 95% CI=1.00-1.01, P=0.045), number of transferred embryos (AOR=1.98, 95% CI=1.47-2.70, P<0.01), and type of transferred embryo (AOR=3.10, 95% CI=2.27-4.23, P<0.01) were independent factors influencing the clinical pregnancy rate. The mean PI (AOR=0.85, 95% CI=0.70-1.05; P=0.13) was not an independent factor influencing the clinical pregnancy rate. Participants were divided into two groups according to the mean PI cutoff value of 1.75, and there was no significant difference between the two groups (P > 0.05).
UNASSIGNED: In this study, we found that the uterine artery PI on the day of endometrial transformation in patients undergoing FET is not a good predictor of pregnancy outcomes.
摘要：
■目的是通过测量冻融胚胎移植（FET）患者子宫内膜转化当天的子宫动脉血流，分析子宫动脉搏动指数（PI）对妊娠结局的影响。
■这是一项病例对照研究。总的来说,纳入2019年10月至2020年9月在郑州大学第三附属医院接受FET的2,036例患者。根据妊娠结局将患者分为临床妊娠组和非临床妊娠组。采用多因素logistic回归模型分析影响临床妊娠率的因素。接收器工作特征（ROC）曲线用于确定1.75的最佳平均PI截止值。1:1倾向评分匹配(PSM)后，562例患者纳入。为了进行统计描述和分析，将患者分为两组:平均PI>1.75的组和平均PI≤1.75的组.
■临床妊娠组包括1,218个周期，非临床妊娠组包括818个周期.女性年龄差异有统计学意义(P<0.01),不孕类型（P=0.04），基线卵泡刺激素水平（P=0.04），抗苗勒管激素(AMH)水平(P<0.01),窦卵泡计数(P<0.01),移植胚胎数(P=0.045)和移植胚胎类型(P<0.01)。平均双侧PI无显著差异(1.98±0.34vs.1.95±0.35,P=0.10)。多因素分析结果显示,产妇年龄(AOR=0.95,95%CI=0.93～0.98,P<0.01),AMH水平(AOR=1.00,95%CI=1.00-1.01,P=0.045),移植胚胎数(AOR=1.98,95%CI=1.47-2.70,P<0.01),移植胚胎类型（AOR=3.10，95％CI=2.27-4.23，P<0.01）是影响临床妊娠率的独立因素。平均PI（AOR=0.85，95％CI=0.70-1.05；P=0.13）不是影响临床妊娠率的独立因素。按平均PI截止值1.75分为两组,两组比较差异无统计学意义(P>0.05)。
■在这项研究中，我们发现,FET患者子宫内膜转化当天的子宫动脉PI并不能很好地预测妊娠结局.
■这是一项病例对照研究。总的来说,纳入2019年10月至2020年9月在郑州大学第三附属医院接受FET的2,036例患者。根据妊娠结局将患者分为临床妊娠组和非临床妊娠组。采用多因素logistic回归模型分析影响临床妊娠率的因素。接收器工作特征（ROC）曲线用于确定1.75的最佳平均PI截止值。1:1倾向评分匹配(PSM)后，562例患者纳入。为了进行统计描述和分析，将患者分为两组:平均PI>1.75的组和平均PI≤1.75的组.
■临床妊娠组包括1,218个周期，非临床妊娠组包括818个周期.女性年龄差异有统计学意义(P<0.01),不孕类型（P=0.04），基线卵泡刺激素水平（P=0.04），抗苗勒管激素(AMH)水平(P<0.01),窦卵泡计数(P<0.01),移植胚胎数(P=0.045)和移植胚胎类型(P<0.01)。平均双侧PI无显著差异(1.98±0.34vs.1.95±0.35,P=0.10)。多因素分析结果显示,产妇年龄(AOR=0.95,95%CI=0.93～0.98,P<0.01),AMH水平(AOR=1.00,95%CI=1.00-1.01,P=0.045),移植胚胎数(AOR=1.98,95%CI=1.47-2.70,P<0.01),移植胚胎类型（AOR=3.10，95％CI=2.27-4.23，P<0.01）是影响临床妊娠率的独立因素。平均PI（AOR=0.85，95％CI=0.70-1.05；P=0.13）不是影响临床妊娠率的独立因素。按平均PI截止值1.75分为两组,两组比较差异无统计学意义(P>0.05)。
■在这项研究中，我们发现,FET患者子宫内膜转化当天的子宫动脉PI并不能很好地预测妊娠结局.
