MEN1 缺乏稳定 PD - L1 并促进肺癌的肿瘤免疫逃避。
关键词: MEN1 CSN5 PD‐L1 immune evasion lung cancer
Mesh : Animals B7-H1 Antigen / metabolism genetics Lung Neoplasms / genetics immunology pathology Mice Humans Proto-Oncogene Proteins / genetics metabolism Tumor Escape / genetics COP9 Signalosome Complex / genetics metabolism Tumor Microenvironment / immunology Adenocarcinoma of Lung / genetics immunology pathology metabolism Cell Line, Tumor CD8-Positive T-Lymphocytes / immunology metabolism Proto-Oncogene Proteins p21(ras) / genetics Ubiquitination Mutation
来 源:
DOI:10.1111/cas.16196
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