Abstract：
Skin is the largest organ of the human body functioning as a great primitive defensive barrier against different harmful environmental factors. However, it is damaged through varying injuries such as different wounds, burns, and skin cancers that cause disruption in internal organs and essential mechanisms of the body through inflammation, oxidation, coagulation problems, infection, etc. Melatonin is the major hormone of the pineal gland that is also effective in skin disorders due to strong antioxidant and anti-inflammatory features with additional desirable antiapoptotic, anti-cancer, and antibiotic properties. However, melatonin characteristics require improvements due to its limited water solubility, halflife and stability. The application of nanocarrier systems can improve its solubility, permeability, and efficiency, as well as inhibit its degradation and promote photostability. Our main purpose in the current review is to explore the possible role of melatonin and melatonin-containing nanocarriers in skin disorders focused on wounds. Additionally, melatonin\'s effect in regenerative medicine and its structures as a wound dressing in skin damage has been considered.
摘要：
皮肤是人体最大的器官，是抵抗各种有害环境因素的巨大原始防御屏障。然而,它因不同的伤害而受损，如不同的伤口，烧伤,和皮肤癌通过炎症导致内部器官和身体基本机制的破坏，氧化，凝血问题，感染,等。褪黑激素是松果体的主要激素，由于具有强大的抗氧化和抗炎功能，还具有其他理想的抗凋亡作用，因此在皮肤病中也有效。抗癌，和抗生素特性。然而,由于其有限的水溶性，褪黑激素的特性需要改进，半衰期和稳定性。纳米载体体系的应用可以提高其溶解性,渗透性,和效率，以及抑制其降解和促进光稳定性。我们在本综述中的主要目的是探索褪黑激素和含褪黑激素的纳米载体在集中于伤口的皮肤病中的可能作用。此外,褪黑素在再生医学中的作用及其作为伤口敷料在皮肤损伤中的作用已被考虑。
