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Abstract：
BACKGROUND: The purpose of this study was to investigate the effects of intravenous anesthetic drugs on fertilization rate in subjects receiving oocyte retrieval by assisted reproduction technology (ART).
METHODS: A retrospective cohort study was designed. The clinical information of subjects who received oocyte retrieval procedure was collected. The subjects were divided into two groups based on the type of anesthesia used: the no-anesthesia group and the intravenous anesthesia group. Propensity score matching (PSM) was performed and multiple linear regression analyses were conducted. Fertilization rate was compared between the two groups before and after PSM.
RESULTS: A total of 765 subjects were divided into two groups: the no-anesthesia group (n = 482) and the intravenous anesthesia group (n = 283). According to propensity scores, 258 pairs of subjects were well matched, and the baseline data between the two groups were not significantly different (P > 0.05). Fertilization rate was 77% in the intravenous anesthesia group, and 76% in the no-anesthesia group, without significant between-group difference (P = 0.685). Before matching, Poisson regression analysis showed no effect of intravenous anesthetic drugs on fertilization rate (RR = 0.859, 95%CI: 0.59 to 1.25, P = 0.422). After matching, no difference was found either (RR = 0.935, 95%CI: 0.67 to 1.29, P = 0.618).
CONCLUSIONS: Intravenous anesthetic drugs may exert no effects on fertilization rate in subjects receiving ART.
METHODS: A retrospective cohort study was designed. The clinical information of subjects who received oocyte retrieval procedure was collected. The subjects were divided into two groups based on the type of anesthesia used: the no-anesthesia group and the intravenous anesthesia group. Propensity score matching (PSM) was performed and multiple linear regression analyses were conducted. Fertilization rate was compared between the two groups before and after PSM.
RESULTS: A total of 765 subjects were divided into two groups: the no-anesthesia group (n = 482) and the intravenous anesthesia group (n = 283). According to propensity scores, 258 pairs of subjects were well matched, and the baseline data between the two groups were not significantly different (P > 0.05). Fertilization rate was 77% in the intravenous anesthesia group, and 76% in the no-anesthesia group, without significant between-group difference (P = 0.685). Before matching, Poisson regression analysis showed no effect of intravenous anesthetic drugs on fertilization rate (RR = 0.859, 95%CI: 0.59 to 1.25, P = 0.422). After matching, no difference was found either (RR = 0.935, 95%CI: 0.67 to 1.29, P = 0.618).
CONCLUSIONS: Intravenous anesthetic drugs may exert no effects on fertilization rate in subjects receiving ART.
摘要：
背景：这项研究的目的是研究静脉麻醉药物对接受辅助生殖技术（ART）取卵的受试者的受精率的影响。
方法：设计了一项回顾性队列研究。收集接受卵母细胞提取程序的受试者的临床信息。根据所使用的麻醉类型将受试者分为两组：非麻醉组和静脉麻醉组。进行倾向评分匹配（PSM）并进行多元线性回归分析。比较两组PSM前后的受精率。
结果：共有765名受试者分为两组：非麻醉组（n=482）和静脉麻醉组（n=283）。根据倾向得分，258对受试者匹配良好，两组基线资料比较差异无统计学意义(P>0.05)。静脉麻醉组受精率为77%,无麻醉组76%,组间差异无统计学意义(P=0.685)。匹配之前,Poisson回归分析显示静脉麻醉药物对受精率无影响(RR=0.859,95CI:0.59~1.25,P=0.422)。匹配后,也没有发现差异（RR=0.935，95CI：0.67至1.29，P=0.618）。
结论：静脉麻醉药物可能对接受ART的受精率没有影响。
方法：设计了一项回顾性队列研究。收集接受卵母细胞提取程序的受试者的临床信息。根据所使用的麻醉类型将受试者分为两组：非麻醉组和静脉麻醉组。进行倾向评分匹配（PSM）并进行多元线性回归分析。比较两组PSM前后的受精率。
结果：共有765名受试者分为两组：非麻醉组（n=482）和静脉麻醉组（n=283）。根据倾向得分，258对受试者匹配良好，两组基线资料比较差异无统计学意义(P>0.05)。静脉麻醉组受精率为77%,无麻醉组76%,组间差异无统计学意义(P=0.685)。匹配之前,Poisson回归分析显示静脉麻醉药物对受精率无影响(RR=0.859,95CI:0.59~1.25,P=0.422)。匹配后,也没有发现差异（RR=0.935，95CI：0.67至1.29，P=0.618）。
结论：静脉麻醉药物可能对接受ART的受精率没有影响。
