Abstract：
A new labdane diterpene (1), two new norsesquiterpenoids (2-3), as well as eight known terpenoids (4-11) were isolated from the seeds of Alpinia galanga (Zingiberaceae). Their structures and absolute configurations were elucidated by 1D, 2D NMR, MS, and comparison of their experimental and calculated electronic circular dichroism (ECD). The acetylcholinesterase (AChE) inhibitory activities of all the isolated compounds (1-11) were evaluated and the result showed that compounds 6 and 9 had inhibitory activity against AChE, with IC50 values at 295.70 and 183.91 μM, whereas other compounds did not show any inhibitory activity.
摘要：
一种新的拉布丹二萜(1)，两种新的降倍半萜（2-3），从高良姜（姜科）的种子中分离出八种已知的萜类化合物（4-11）。它们的结构和绝对构型由1D阐明，2DNMR,MS,以及他们的实验和计算电子圆二色性（ECD）的比较。对所有分离的化合物(1-11)的乙酰胆碱酯酶(AChE)抑制活性进行了评价,结果表明化合物6和9对AChE具有抑制活性,IC50值为295.70和183.91μM，而其他化合物没有显示任何抑制活性。
