Abstract：
UNASSIGNED: Burn injuries pose a heightened risk of infection, which is primarily responsible for increased morbidity and mortality. Factors such as extensive skin damage and compromised immunity exacerbate this vulnerability. Pseudomonas aeruginosa and Staphylococcus aureus are frequently identified in burns, with Gram-negative Pseudomonas aeruginosa often resistant to antibacterial agents. While Flaminal, an alginate-based wound dressing (Flen Health, Belgium), aids wound healing, its antibacterial effects are limited compared with 1% silver sulfadiazine (1% SSD). In contrast, Prontosan Wound Gel X, a betaine and polyhexanide-based hydrogel (B. Braun Medical AG, Switzerland), has been shown to effectively combat various microbes and promotes wound healing.
UNASSIGNED: In this study, two research cohorts were retrospectively established (control group: patients receiving standard of care with the alginate-based wound dressing; intervention group: patients receiving the polyhexanide hydrogel wound dressing), comprising patients admitted to a burn centre between 2019 and 2022. Patients were eligible when continuous wound treatment with either of the two wound dressings was performed. Laser Doppler imaging (LDI) scans were conducted. Regions of interest (ROIs) were selected based on LDI scans and divided into healing time categories. Wound swabs were collected and the presence of Pseudomonas aeruginosa and Staphylococcus aureus was documented. Bacterial load was evaluated using a semiquantitative scale. Wound healing was recorded.
UNASSIGNED: The control group consisted of 31 patients with 93 ROIs, while the intervention group had 67 ROIs involving 29 patients. Both groups exhibited similar proportions of healing time categories (p>0.05). The polyhexanide hydrogel dressing outperformed the alginate-based dressing in antiseptic efficacy by significantly reducing the incidence of Pseudomonas aeruginosa- and Staphylococcus aureus-positive cultures in patients\' wounds. Wound healing time for conservative treatment was comparable between groups.
UNASSIGNED: In this study, the polyhexanide hydrogel dressing minimised Pseudomonas aeruginosa and Staphylococcus aureus colonisation in burn wounds, demonstrating strong antibacterial properties, emphasising its potential to minimise infections in burn injuries.
UNASSIGNED: In this study, two research cohorts were retrospectively established (control group: patients receiving standard of care with the alginate-based wound dressing; intervention group: patients receiving the polyhexanide hydrogel wound dressing), comprising patients admitted to a burn centre between 2019 and 2022. Patients were eligible when continuous wound treatment with either of the two wound dressings was performed. Laser Doppler imaging (LDI) scans were conducted. Regions of interest (ROIs) were selected based on LDI scans and divided into healing time categories. Wound swabs were collected and the presence of Pseudomonas aeruginosa and Staphylococcus aureus was documented. Bacterial load was evaluated using a semiquantitative scale. Wound healing was recorded.
UNASSIGNED: The control group consisted of 31 patients with 93 ROIs, while the intervention group had 67 ROIs involving 29 patients. Both groups exhibited similar proportions of healing time categories (p>0.05). The polyhexanide hydrogel dressing outperformed the alginate-based dressing in antiseptic efficacy by significantly reducing the incidence of Pseudomonas aeruginosa- and Staphylococcus aureus-positive cultures in patients\' wounds. Wound healing time for conservative treatment was comparable between groups.
UNASSIGNED: In this study, the polyhexanide hydrogel dressing minimised Pseudomonas aeruginosa and Staphylococcus aureus colonisation in burn wounds, demonstrating strong antibacterial properties, emphasising its potential to minimise infections in burn injuries.
摘要：
■烧伤会增加感染的风险，这是发病率和死亡率增加的主要原因。广泛的皮肤损伤和免疫力受损等因素加剧了这种脆弱性。铜绿假单胞菌和金黄色葡萄球菌经常在烧伤中被发现，革兰阴性铜绿假单胞菌常对抗菌药物耐药。而Flaminal,基于藻酸盐的伤口敷料(FlenHealth，比利时),有助于伤口愈合，与1％磺胺嘧啶银（1％SSD）相比，其抗菌作用有限。相比之下,Prontosan伤口凝胶X,基于甜菜碱和聚己内酯的水凝胶(B.BraunMedicalAG,瑞士),已被证明可以有效对抗各种微生物并促进伤口愈合。
■在这项研究中，回顾性建立了两个研究队列（对照组：接受基于藻酸盐的伤口敷料的标准护理的患者；干预组：接受聚己内酯水凝胶伤口敷料的患者），包括2019年至2022年期间入住烧伤中心的患者。当使用两种伤口敷料中的任一种进行连续伤口处理时,患者是合格的。进行激光多普勒成像(LDI)扫描。基于LDI扫描选择感兴趣区域(ROI)并将其分成愈合时间类别。收集伤口拭子并记录铜绿假单胞菌和金黄色葡萄球菌的存在。使用半定量量表评估细菌负荷。记录伤口愈合情况。
■对照组由31名患者组成，有93个ROI，而干预组有67个ROI，涉及29例患者。两组的愈合时间类别比例相似(p>0.05)。通过显着降低患者伤口中铜绿假单胞菌和金黄色葡萄球菌阳性培养物的发生率，聚己内酯水凝胶敷料在防腐功效方面优于基于藻酸盐的敷料。两组保守治疗的伤口愈合时间具有可比性。
■在这项研究中，聚己内酯水凝胶敷料最大限度地减少了铜绿假单胞菌和金黄色葡萄球菌在烧伤伤口中的定植，表现出强大的抗菌性能，强调其减少烧伤感染的潜力。
■在这项研究中，回顾性建立了两个研究队列（对照组：接受基于藻酸盐的伤口敷料的标准护理的患者；干预组：接受聚己内酯水凝胶伤口敷料的患者），包括2019年至2022年期间入住烧伤中心的患者。当使用两种伤口敷料中的任一种进行连续伤口处理时,患者是合格的。进行激光多普勒成像(LDI)扫描。基于LDI扫描选择感兴趣区域(ROI)并将其分成愈合时间类别。收集伤口拭子并记录铜绿假单胞菌和金黄色葡萄球菌的存在。使用半定量量表评估细菌负荷。记录伤口愈合情况。
■对照组由31名患者组成，有93个ROI，而干预组有67个ROI，涉及29例患者。两组的愈合时间类别比例相似(p>0.05)。通过显着降低患者伤口中铜绿假单胞菌和金黄色葡萄球菌阳性培养物的发生率，聚己内酯水凝胶敷料在防腐功效方面优于基于藻酸盐的敷料。两组保守治疗的伤口愈合时间具有可比性。
■在这项研究中，聚己内酯水凝胶敷料最大限度地减少了铜绿假单胞菌和金黄色葡萄球菌在烧伤伤口中的定植，表现出强大的抗菌性能，强调其减少烧伤感染的潜力。
