Abstract：
Ultrasound has expanded into the therapeutic field as a medical imaging and diagnostic technique. Low-intensity pulsed ultrasound (LIPUS) is a kind of therapeutic ultrasound that plays a vital role in promoting fracture healing, wound repair, immunomodulation, and reducing inflammation. Its anti-inflammatory effects are manifested by decreased pro-inflammatory cytokines and chemokines, accelerated regression of immune cell invasion, and accelerated damage repair. Although the anti-inflammatory mechanism of LIPUS is not very clear, many in vitro and in vivo studies have shown that LIPUS may play its anti-inflammatory role by activating signaling pathways such as integrin/Focal adhesion kinase (FAK)/Phosphatidylinositol 3-kinase (PI3K)/Serine threonine kinase (Akt), Vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS), or inhibiting signaling pathways such as Toll-like receptors (TLRs)/Nuclear factor kappa-B (NF-κB) and p38-Mitogen-activated protein kinase (MAPK). As a non-invasive physical therapy, the anti-inflammatory and immunomodulatory effects of LIPUS deserve further exploration.
摘要：
超声作为医学成像和诊断技术已经扩展到治疗领域。低强度脉冲超声（LIPUS）是一种治疗性超声，在促进骨折愈合中起着至关重要的作用，伤口修复,免疫调节,减少炎症。其抗炎作用表现为促炎细胞因子和趋化因子的减少，加速免疫细胞侵袭的回归，加速损伤修复。虽然LIPUS的抗炎机制还不是很清楚,许多体外和体内研究表明，LIPUS可能通过激活信号通路发挥抗炎作用，如整合素/粘着斑激酶（FAK）/磷脂酰肌醇3-激酶（PI3K）/丝氨酸苏氨酸激酶（Akt），血管内皮生长因子(VEGF)/内皮型一氧化氮合酶(eNOS),或抑制信号传导途径，如Toll样受体（TLRs）/核因子κB（NF-κB）和p38-丝裂原活化蛋白激酶（MAPK）。作为一种非侵入性物理治疗，LIPUS的抗炎和免疫调节作用值得进一步探索。
