Abstract：
Parkinson\'s disease (PD) is a neurodegenerative disease that affects dopaminergic neurons, thus impairing dopaminergic signalling. Quercetin (QUE) has antioxidant and neuroprotective properties that are promising for the treatment of PD. This systematic review aimed to investigate the therapeutic effects of QUE against PD in preclinical models. The systematic search was performed in PubMed, Scopus and Web of Science. At the final screening stage, 26 articles were selected according to pre-established criteria. Selected studies used different methods for PD induction, as well as animal models. Most studies used rats (73.08%) and mice (23.08%), with 6-OHDA as the main strategy for PD induction (38.6%), followed by rotenone (30.8%). QUE was tested immersed in oil, nanosystems or in free formulations, in varied routes of administration and doses, ranging from 10 to 400 mg/kg and from 5 to 200 mg/kg in oral and intraperitoneal administrations, respectively. Overall, evidence from published data suggests a potential use of QUE as a treatment for PD, mainly through the inhibition of oxidative stress, neuroinflammatory response and apoptotic pathways.
摘要：
帕金森病(PD)是一种影响多巴胺能神经元的神经退行性疾病,从而损害多巴胺能信号。槲皮素（QUE）具有抗氧化和神经保护特性，有望用于治疗PD。本系统综述旨在研究QUE在临床前模型中对PD的治疗效果。系统搜索在PubMed中进行，Scopus和WebofScience在最后的筛选阶段,根据预先建立的标准选择了26篇文章。选定的研究使用不同的PD诱导方法，以及动物模型。大多数研究使用大鼠（73.08％）和小鼠（23.08％），以6-OHDA为PD诱导的主要策略（38.6％），其次是鱼藤酮(30.8%)。将QUE浸入油中进行测试，纳米系统或自由配方，在不同的给药途径和剂量中，口服和腹膜内给药范围为10至400mg/kg和5至200mg/kg，分别。总的来说,来自已发表数据的证据表明，QUE可能用作PD的治疗方法，主要通过抑制氧化应激，神经炎症反应和凋亡途径。
