PDF(Pubmed)
Abstract：
UNASSIGNED: Given the traffic safety and occupational injury prevention implications associated with cannabis impairment, there is a need for objective and validated measures of recent cannabis use. Pupillary light response may offer an approach for detection.
UNASSIGNED: Eighty-four participants (mean age: 32, 42% female) with daily, occasional, and no-use cannabis use histories participated in pupillary light response tests before and after smoking cannabis ad libitum or relaxing for 15 min (no use). The impact of recent cannabis consumption on trajectories of the pupillary light response was modeled using functional data analysis tools. Logistic regression models for detecting recent cannabis use were compared, and average pupil trajectories across cannabis use groups and times since light test administration were estimated.
UNASSIGNED: Models revealed small, significant differences in pupil response to light after cannabis use comparing the occasional use group to the no-use control group, and similar statistically significant differences in pupil response patterns comparing the daily use group to the no-use comparison group. Trajectories of pupillary light response estimated using functional data analysis found that acute cannabis smoking was associated with less initial and sustained pupil constriction compared to no cannabis smoking.
UNASSIGNED: These analyses show the promise of pairing pupillary light response and functional data analysis methods to assess recent cannabis use.
UNASSIGNED: Eighty-four participants (mean age: 32, 42% female) with daily, occasional, and no-use cannabis use histories participated in pupillary light response tests before and after smoking cannabis ad libitum or relaxing for 15 min (no use). The impact of recent cannabis consumption on trajectories of the pupillary light response was modeled using functional data analysis tools. Logistic regression models for detecting recent cannabis use were compared, and average pupil trajectories across cannabis use groups and times since light test administration were estimated.
UNASSIGNED: Models revealed small, significant differences in pupil response to light after cannabis use comparing the occasional use group to the no-use control group, and similar statistically significant differences in pupil response patterns comparing the daily use group to the no-use comparison group. Trajectories of pupillary light response estimated using functional data analysis found that acute cannabis smoking was associated with less initial and sustained pupil constriction compared to no cannabis smoking.
UNASSIGNED: These analyses show the promise of pairing pupillary light response and functional data analysis methods to assess recent cannabis use.
摘要：
■鉴于与大麻损害相关的交通安全和职业伤害预防影响，有必要对最近的大麻使用采取客观和有效的措施。瞳孔光响应可以提供用于检测的方法。
■84名参与者（平均年龄：32岁，42％为女性）每天，偶尔,和不使用大麻的使用历史参加瞳孔光反应测试前后随意吸食大麻或放松15分钟(不使用)。使用功能数据分析工具对最近的大麻消费对瞳孔光响应轨迹的影响进行了建模。比较了检测近期大麻使用的Logistic回归模型，以及自进行光测试以来，使用大麻组和时间的平均瞳孔轨迹进行了估计。
■模型显示小，偶尔使用组与不使用对照组相比，使用大麻后瞳孔对光的反应存在显着差异，与日常使用组与不使用比较组相比，瞳孔反应模式的统计学差异相似。使用功能数据分析估计的瞳孔光响应轨迹发现，与不吸烟相比，急性大麻吸烟与较少的初始和持续瞳孔收缩相关。
■这些分析显示了配对瞳孔光响应和功能数据分析方法以评估最近的大麻使用的前景。
■84名参与者（平均年龄：32岁，42％为女性）每天，偶尔,和不使用大麻的使用历史参加瞳孔光反应测试前后随意吸食大麻或放松15分钟(不使用)。使用功能数据分析工具对最近的大麻消费对瞳孔光响应轨迹的影响进行了建模。比较了检测近期大麻使用的Logistic回归模型，以及自进行光测试以来，使用大麻组和时间的平均瞳孔轨迹进行了估计。
■模型显示小，偶尔使用组与不使用对照组相比，使用大麻后瞳孔对光的反应存在显着差异，与日常使用组与不使用比较组相比，瞳孔反应模式的统计学差异相似。使用功能数据分析估计的瞳孔光响应轨迹发现，与不吸烟相比，急性大麻吸烟与较少的初始和持续瞳孔收缩相关。
■这些分析显示了配对瞳孔光响应和功能数据分析方法以评估最近的大麻使用的前景。
