PDF(Pubmed)
Abstract：
Glucocorticoid withdrawal syndrome is a challenging clinical phenomenon that can complicate the postsurgical recovery of Cushing syndrome. It is characterized by physical tolerance and dependence to supraphysiologic glucocorticoid exposure during active Cushing syndrome followed by the abrupt decline in cortisol levels after surgical treatment. The symptoms of glucocorticoid withdrawal often overlap with those of postoperative adrenal insufficiency and can be difficult for patients to cope with and for clinicians to treat. This mini review will discuss the clinical characteristics, pathophysiology, and management of glucocorticoid withdrawal syndrome while highlighting recent data in the field.
摘要：
糖皮质激素戒断综合征是一种具有挑战性的临床现象，可使库欣综合征的术后恢复复杂化。其特征是在活动性库欣综合征期间对身体的耐受性和对超生理糖皮质激素暴露的依赖性，随后在手术治疗后皮质醇水平突然下降。糖皮质激素戒断的症状通常与术后肾上腺功能不全的症状重叠，患者难以应对，临床医生难以治疗。这篇迷你综述将讨论其临床特征，病理生理学,以及糖皮质激素戒断综合征的管理，同时突出该领域的最新数据。
