PDF(Pubmed)
Abstract：
Introduction Serum urea and creatinine levels are the most commonly recognized parameters for evaluating renal impairment in patients with diabetes mellitus (DM). Therefore, this study evaluated the correlation between urea and creatinine levels and thiamin levels in patients with type 1 DM (T1DM) and type 2 DM (T2DM). Methods This multi-center, cross-sectional study was conducted at diabetic outpatient clinics in Karachi. The duration of the study was six months, from 1st January 2023 to 30th June 2023. A total of 60 patients were enrolled and divided into two groups, i.e., T1DM and T2DM, each containing 30 patients of both genders between the ages of 24 and 42 years. Demographic data and biochemical variables, such as urea, creatinine, random blood sugar, fasting blood sugar, hemoglobin A1c, and serum thiamin levels, were assessed. The Mann-Whitney U test and independent t-test were used to associate the means between the two study groups. The chi-square test and Spearman\'s correlation coefficient were used to determine the associations between the variables and T1DM and T2DM. Results The study results revealed that patients with T2DM had a significantly higher frequency of hypertension (p = 0.039), neuropathy (p = 0.038), and coronary artery disease (p = 0.010) than those with T1DM, in both genders. The level of serum thiamin was found to be significantly higher (p < 0.001) in T2DM (14.8 ± 4.82) than in T1DM patients (7.34 ± 1.90). Similarly, serum creatinine was higher in T2DM than in T1DM patients (0.83 ± 0.12 vs. 0.76 ± 0.17, p = 0.025). Moreover, the correlation of urea and creatinine with thiamin levels in T1DM and T2DM patients revealed that in T1DM and T2DM patients, urea and creatinine showed an insignificant positive correlation with thiamin levels. Conclusion We found a significantly higher level of serum creatinine and thiamin levels in T2DM patients than in T1DM; however, there was no significant correlation between urea and creatinine levels and thiamin status in T1DM and T2DM patients. Therefore, we conclude that although serum urea, creatinine, and serum thiamin are important disease biomarkers in diabetic patients, there is no correlation between them.
摘要：
简介血清尿素和肌酐水平是评估糖尿病（DM）患者肾损害的最常见参数。因此,这项研究评估了1型DM(T1DM)和2型DM(T2DM)患者尿素和肌酐水平与硫胺素水平之间的相关性.方法这种多中心,在卡拉奇的糖尿病门诊进行了横断面研究.研究时间为六个月，从2023年1月1日至2023年6月30日。共纳入60例患者，分为两组，即，T1DM和T2DM,每个包含30名年龄在24至42岁之间的男女患者。人口统计数据和生化变量，如尿素，肌酐,随机血糖,空腹血糖,血红蛋白A1c，和血清硫胺素水平，被评估。使用Mann-WhitneyU检验和独立t检验来关联两个研究组之间的均值。采用卡方检验和Spearman相关系数确定变量与T1DM和T2DM的相关性。结果2型糖尿病患者高血压的发生频率明显增高(p=0.039),神经病变（p=0.038），和冠状动脉疾病（p=0.010）比患有T1DM的人，在两个性别。发现T2DM患者的血清硫胺素水平（14.8±4.82）明显高于T1DM患者（7.34±1.90）（p<0.001）。同样，T2DM患者的血清肌酐高于T1DM患者（0.83±0.12vs.0.76±0.17，p=0.025）。此外，T1DM和T2DM患者尿素和肌酐水平与硫胺素水平的相关性显示,尿素和肌酐与硫胺素水平无显著正相关。结论T2DM患者的血肌酐和硫胺素水平明显高于T1DM患者;T1DM和T2DM患者的尿素和肌酐水平与硫胺素状态之间无显著相关性.因此,我们得出结论，虽然血清尿素，肌酐,血清硫胺素是糖尿病患者的重要疾病生物标志物,它们之间没有相关性。
