PDF(Pubmed)
Abstract：
Doxycycline is one of the medications that cause drug-induced esophagitis. This condition occurs due to prolonged contact of the medications with the esophageal mucosa, leading to erosion, ulcers, and, in some cases, stricture of the esophagus. Chest pain, dysphagia, and odynophagia are the most common symptoms. Endoscopy is the gold standard for confirming the diagnosis. The treatment consists of stopping the offending medication and starting proton pump inhibitors (PPIs) and sucralfate. Herein, we describe a middle-aged man who presented with severe chest pain, odynophagia, and dysphagia that started two hours after ingesting the first doxycycline pill. An endoscopy showed multiple longitudinal ulcers in the distal esophagus. Symptoms significantly improved after starting a PPI and sucralfate, and feeding was resumed two days later. A follow-up with endoscopy after two months reported completely healed esophageal ulcers. In conclusion, doxycycline-induced esophageal injury is often an underdiagnosed and underreported condition. Physicians and patients should be more aware of doxycycline\'s detrimental effect on the esophagus, as it can induce esophageal ulceration even after a single dose if not administered properly. Therefore, all patients prescribed oral doxycycline should receive appropriate instructions to minimize this side effect.
摘要：
强力霉素是引起药物性食管炎的药物之一。这种情况是由于药物与食道粘膜的长期接触而发生的，导致侵蚀，溃疡,and,在某些情况下,食管狭窄.胸痛,吞咽困难,和吞咽困难是最常见的症状。内窥镜检查是确认诊断的金标准。治疗包括停止不良药物并开始使用质子泵抑制剂（PPI）和硫糖铝。在这里，我们描述了一个出现严重胸痛的中年男子，吞咽困难,和吞咽困难，在摄入第一个多西环素药丸两小时后开始。内窥镜检查显示食管远端有多个纵向溃疡。开始PPI和硫糖铝后症状显着改善，两天后恢复进食。两个月后的内镜随访报告食管溃疡完全愈合。总之,多西环素引起的食管损伤通常是一种未被诊断和未被报道的疾病。医生和患者应该更多地了解多西环素对食道的不利影响，因为它可以诱发食道溃疡，即使在单剂量后，如果不正确给药。因此,所有口服多西环素的患者都应接受适当的指导，以尽量减少这种副作用。
