关键词: Chronic intestinal pseudo-obstruction Gut Inflammation Microbiota Motility Pathogenesis Vitamin D

Mesh : Humans Gastrointestinal Microbiome / immunology physiology Gastrointestinal Motility / physiology Intestines / microbiology immunology physiopathology Inflammation / immunology physiopathology Inflammatory Bowel Diseases / immunology microbiology physiopathology Intestinal Mucosa / immunology microbiology pathology Animals

来  源:   DOI:10.3748/wjg.v30.i14.1963   PDF(Pubmed)

Abstract:
Digestion and intestinal absorption allow the body to sustain itself and are the emblematic functions of the bowel. On the flip side, functions also arise from its role as an interface with the environment. Indeed, the gut houses microorganisms, collectively known as the gut microbiota, which interact with the host, and is the site of complex immune activities. Its role in human pathology is complex and scientific evidence is progressively elucidating the functions of the gut, especially regarding the pathogenesis of chronic intestinal diseases and inflammatory conditions affecting various organs and systems. This editorial aims to highlight and relate the factors involved in the pathogenesis of intestinal and systemic inflammation.
摘要:
消化和肠道吸收使身体能够维持自身,并且是肠道的象征性功能。另一方面,功能也源于其作为与环境的接口的角色。的确,肠道容纳微生物,统称为肠道微生物群,与主机交互,是复杂免疫活动的部位。它在人类病理学中的作用是复杂的,科学证据正在逐步阐明肠道的功能,特别是关于影响各种器官和系统的慢性肠道疾病和炎症的发病机理。这篇社论旨在强调和联系肠道和全身性炎症发病机制中涉及的因素。
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