PDF(Pubmed)
Abstract：
Nephrotic syndrome (NS) is one of the common presentations of kidney diseases both in children and adults. NS patients, particularly those with membranous nephropathy, have increased risk of thromboembolic events. Heparin and vitamin K antagonists (VKAs) continue to be commonly used as prophylactic and therapeutic agents, given the experience of use of these agents in NS and nonrenal indications of anticoagulation. The use of direct oral anticoagulants (DOACs) in NS is reported in some case series, conference abstracts, and a few small studies. We report our experience of using DOACs in 11 patients of NS with severe hypoalbuminemia. Out of 11, one patient required change of anticoagulation from DOACs to VKA and the rest of them did well with DOACs. There were no bleeding episodes in our study. We suggest larger studies to be carried out to better understand the use of these agents in NS.
摘要：
肾病综合征（NS）是儿童和成人肾脏疾病的常见表现之一。NS患者，尤其是那些患有膜性肾病的人，血栓栓塞事件的风险增加。肝素和维生素K拮抗剂（VKAs）继续被广泛用作预防和治疗药物。鉴于在NS和非肾脏抗凝适应症中使用这些药物的经验。在某些病例系列中报道了在NS中使用直接口服抗凝剂（DOAC）。会议摘要，和一些小的研究。我们报告了在11例严重低白蛋白血症的NS患者中使用DOAC的经验。在11名患者中，一名患者需要将抗凝药物从DOAC改为VKA，其余患者使用DOAC效果良好。在我们的研究中没有出血事件。我们建议进行更大的研究，以更好地了解这些药物在NS中的使用。
