UNASSIGNED: In this population-based retrospective cohort study, health data from 2007 to 2019 in Ontario, Canada were analyzed (n = 37, 375 patients identified with spine metastases). Primary outcomes were annual incidence of spinal metastasis, and time to metastasis after primary diagnosis.
UNASSIGNED: The age-standardized incidence of spinal metastases increased from 229 to 302 cases per million over the 13-year study period. The average annual percent change (AAPC) in incidence was 2.2% (95% CI: 1.4% to 3.0%) with patients aged ≥85 years demonstrating the largest increase (AAPC 5.2%; 95% CI: 2.3% to 8.3%). Lung cancer had the greatest annual incidence, while prostate cancer had the greatest increase in annual incidence (AAPC 6.5; 95% CI: 4.1% to 9.0%). Lung cancer patients were found to have the highest risk of spine metastasis with 10.3% (95% CI: 10.1% to 10.5%) of patients being diagnosed at 10 years. Gastrointestinal cancer patients were found to have the lowest risk of spine metastasis with 1.0% (95% CI: 0.9% to 1.0%) of patients being diagnosed at 10 years.
UNASSIGNED: The incidence of spinal metastases has increased in recent years, particularly among older patients. The incidence and timing vary substantially among different primary cancer types. These findings contribute to the understanding of disease trends and emphasize a growing population of patients who require subspecialty care.
■在这项基于人群的回顾性队列研究中,安大略省2007年至2019年的健康数据,加拿大进行了分析(n=37,375例确定为脊柱转移的患者)。主要结果是脊柱转移的年发病率,和初次诊断后转移的时间。
■在13年的研究期间,脊柱转移的年龄标准化发生率从每百万229例增加到302例。发病率的平均年变化百分比(AAPC)为2.2%(95%CI:1.4%至3.0%),年龄≥85岁的患者表现出最大的增长(AAPC5.2%;95%CI:2.3%至8.3%)。肺癌的年发病率最高,而前列腺癌的年发病率增幅最大(AAPC6.5;95%CI:4.1%~9.0%).发现肺癌患者脊柱转移的风险最高,其中10.3%(95%CI:10.1%至10.5%)的患者在10年被诊断。发现胃肠道癌症患者的脊柱转移风险最低,其中1.0%(95%CI:0.9%至1.0%)的患者在10年被诊断。
■脊柱转移瘤的发病率近年来有所上升,尤其是老年患者。发病率和时间在不同的原发癌类型之间有很大差异。这些发现有助于了解疾病趋势,并强调需要亚专科护理的患者人数不断增加。