PDF(Pubmed)
Abstract：
A large number of microbial species tend to communicate and produce biofilm which causes numerous microbial infections, antibiotic resistance, and economic problems across different industries. Therefore, advanced anti-biofilms are required with novel attributes and targets, such as quorum sensing communication system. Meanwhile, quorum sensing inhibitors as promising anti-biofilm molecules result in the inhibition of particular phenotype expression blocking of cell-to-cell communication, which would be more acceptable than conventional strategies. Many natural products are identified as anti-biofilm agents from different plants, microorganisms, and marine extracts. Marine algae are promising sources of broadly novel compounds with anti-biofilm activity. Algae extracts and their metabolites such as sulfated polysaccharides (fucoidan), carotenoids (zeaxanthin and lutein), lipid and fatty acids (γ-linolenic acid and linoleic acid), and phlorotannins can inhibit the cell attachment, reduce the cell growth, interfere in quorum sensing pathway by blocking related enzymes, and disrupt extracellular polymeric substances. In this review, the mechanisms of biofilm formation, quorum sensing pathway, and recently identified marine algae natural products as anti-biofilm agents will be discussed.
摘要：
大量的微生物物种倾向于交流和产生生物膜，导致许多微生物感染，抗生素耐药性,以及不同行业的经济问题。因此,先进的抗生物膜需要新的属性和目标，如法定感应通信系统。同时,群体感应抑制剂作为有前途的抗生物膜分子导致抑制特定表型表达阻断细胞间通讯，这将比传统策略更容易接受。许多天然产物被鉴定为来自不同植物的抗生物膜剂，微生物,和海洋提取物。海洋藻类是具有抗生物膜活性的广泛新型化合物的有希望的来源。藻类提取物及其代谢物，如硫酸多糖（岩藻依聚糖），类胡萝卜素（玉米黄质和叶黄素），脂质和脂肪酸（γ-亚麻酸和亚油酸），间氯单宁可以抑制细胞的附着，减少细胞生长，通过阻断相关酶干扰群体感应途径，破坏细胞外聚合物.在这次审查中,生物膜形成的机制，群体感应通路，并将讨论最近确定的海藻天然产物作为抗生物膜剂。
