METHODS: Serum CK18, CK 19, α-fetoprotein, albumin and platelets count were assayed in HCC patients (75), liver cirrhosis patients (55) and healthy control (20). Areas under receiving operating curve (AUCs) were calculated and used for construction on novel score. A novel score named CK-HCC = CK 19 (ng/ml)×0.001+ CK18 (ng/ml)×0.004 + AFP (U/L)×5.4 - Platelets count (×109)/L×0.003 - Albumin (g/L)×0.27-36 was developed. CK-HCC score produces AUC of 0.919 for differentiating patients with HCC from those with liver cirrhosis with sensitivity and specificity of a cut-off 1.3 (i.e., less than 1.3 the case is considered cirrhotic, whereas above 1.3 it is considered HCC.
CONCLUSIONS: CK-HCC score could replace AFP during screening of HCV patients and early detection of HCC.
方法:血清CK18、CK19、甲胎蛋白、在肝癌患者中检测白蛋白和血小板计数(75),肝硬化患者(55)和健康对照(20)。计算接收操作曲线下的面积(AUC)并用于构建新评分。新评分CK-HCC=CK19(ng/ml)×0.001CK18(ng/ml)×0.004AFP(U/L)×5.4-血小板计数(×109)/L×0.003-白蛋白(g/L)×0.27-36被开发。CK-HCC评分产生0.919的AUC,用于区分HCC患者与肝硬化患者的敏感性和特异性为1.3(即,小于1.3的病例被认为是肝硬化,而高于1.3则被认为是HCC。
结论:CK-HCC评分在HCV患者的筛查和HCC的早期发现中可以替代AFP。