PDF(Pubmed)
Abstract：
Normative ferret brain development was characterized using magnetic resonance imaging. Brain growth was longitudinally monitored in 10 ferrets (equal numbers of males and females) from postnatal day 8 (P8) through P38 in 6-d increments. Template T2-weighted images were constructed at each age, and these were manually segmented into 12 to 14 brain regions. A logistic growth model was used to fit data from whole brain volumes and 8 of the individual regions in both males and females. More protracted growth was found in males, which results in larger brains; however, sex differences were not apparent when results were corrected for body weight. Additionally, surface models of the developing cortical plate were registered to one another using the anatomically-constrained Multimodal Surface Matching algorithm. This, in turn, enabled local logistic growth parameters to be mapped across the cortical surface. A close similarity was observed between surface area expansion timing and previous reports of the transverse neurogenic gradient in ferrets. Regional variation in the extent of surface area expansion and the maximum expansion rate was also revealed. This characterization of normative brain growth over the period of cerebral cortex folding may serve as a reference for ferret studies of brain development.
摘要：
使用磁共振成像表征了规范的雪貂大脑发育。从出生后第8天（P8）到P38，以6天的增量纵向监测了10只雪貂（雄性和雌性数量相等）的脑生长。在每个年龄构建模板T2加权图像，这些被手动分割成12到14个大脑区域。使用逻辑生长模型来拟合来自男性和女性的全脑体积和8个个体区域的数据。在男性中发现了更持久的生长，这导致更大的大脑；然而，对体重进行校正后,性别差异不明显.此外,使用解剖学约束的多模态表面匹配算法将发育中的皮质板的表面模型相互配准。这个,反过来,使局部逻辑生长参数可以映射到整个皮层表面。在雪貂的表面积扩张时间与先前报道的横向神经源性梯度之间观察到了密切的相似性。还揭示了表面积扩展程度和最大扩展速率的区域变化。大脑皮层折叠期间规范大脑生长的这种表征可作为雪貂大脑发育研究的参考。
