PDF(Pubmed)
Abstract：
BACKGROUND: Bowen\'s disease (BD) represents an in situ squamous cell carcinoma that can progress to an invasive one without treatment. Various options for Bowen\'s disease have been delineated, each with its set of advantages and disadvantages.
METHODS: We report the case of a 60-year-old patient with a history of chronic smoking and a background of multiple partners and recurrent urethritis. The patient presented with a maculopapular lesion on the lateral aspect of the penis, evolving for 5 years. A biopsy confirmed the diagnosis of Bowen\'s disease. The patient underwent an excision of the lesion which the histology showed an infiltrating basosquamous cell carcinoma.
CONCLUSIONS: The diagnosis of Bowen\'s disease requires a biopsy and is based on histological examination. Only surgical treatment allows for the identification, through histological analysis of the excised specimen, of any potential invasive area that may not have been identified in the biopsy. Nonsurgical therapies are also an option with high recurrence rates.
CONCLUSIONS: Bowen\'s disease management requires a personalized approach, considering factors like lesion characteristics, patient-related variables and treatment efficacy. An adapted follow-up is recommended due to the recurrence risk associated with various treatments.
METHODS: We report the case of a 60-year-old patient with a history of chronic smoking and a background of multiple partners and recurrent urethritis. The patient presented with a maculopapular lesion on the lateral aspect of the penis, evolving for 5 years. A biopsy confirmed the diagnosis of Bowen\'s disease. The patient underwent an excision of the lesion which the histology showed an infiltrating basosquamous cell carcinoma.
CONCLUSIONS: The diagnosis of Bowen\'s disease requires a biopsy and is based on histological examination. Only surgical treatment allows for the identification, through histological analysis of the excised specimen, of any potential invasive area that may not have been identified in the biopsy. Nonsurgical therapies are also an option with high recurrence rates.
CONCLUSIONS: Bowen\'s disease management requires a personalized approach, considering factors like lesion characteristics, patient-related variables and treatment efficacy. An adapted follow-up is recommended due to the recurrence risk associated with various treatments.
摘要：
背景：Bowen病（BD）代表一种原位鳞状细胞癌，无需治疗即可发展为浸润性鳞状细胞癌。已经描述了鲍恩病的各种选择，每一个都有它的优点和缺点。
方法：我们报告了一例60岁患者，有慢性吸烟史，有多个伴侣和复发性尿道炎的背景。患者表现为阴茎外侧有斑丘疹性病变，进化了5年。活检证实了Bowen病的诊断。该患者接受了病变切除，组织学显示为浸润性基底鳞状细胞癌。
结论：Bowen病的诊断需要活检和组织学检查。只有手术治疗才能进行鉴定，通过对切除标本的组织学分析，活检中可能未发现的任何潜在侵入性区域。非手术疗法也是一种高复发率的选择。
结论：Bowen的疾病管理需要个性化的方法，考虑到病变特征等因素，患者相关变量和治疗效果。由于与各种治疗相关的复发风险，建议进行适应性随访。
方法：我们报告了一例60岁患者，有慢性吸烟史，有多个伴侣和复发性尿道炎的背景。患者表现为阴茎外侧有斑丘疹性病变，进化了5年。活检证实了Bowen病的诊断。该患者接受了病变切除，组织学显示为浸润性基底鳞状细胞癌。
结论：Bowen病的诊断需要活检和组织学检查。只有手术治疗才能进行鉴定，通过对切除标本的组织学分析，活检中可能未发现的任何潜在侵入性区域。非手术疗法也是一种高复发率的选择。
结论：Bowen的疾病管理需要个性化的方法，考虑到病变特征等因素，患者相关变量和治疗效果。由于与各种治疗相关的复发风险，建议进行适应性随访。
