METHODS: A 74-year-old woman with a 40-year smoking history presented with a 2.1 × 1.7 cm lung nodule discovered on computed tomography (CT) scan. A biopsy and subsequent lobe resection were performed, as well as an extensive metastatic work up, which revealed no additional masses. No specific line of differentiation was found by immunohistochemical staining, and an RNA-based fusion panel revealed a MEIS1::NCOA2 fusion, at which point a diagnosis of Low-Grade Undifferentiated Sarcoma with MEIS1::NCOA2-Rearrangement was rendered.
CONCLUSIONS: This report represents the first diagnosis of this tumor primary to the lung, and provides additional insight into the origin and localization of these rare tumors.
方法:一名74岁女性,有40年吸烟史,在计算机断层扫描(CT)扫描中发现2.1×1.7cm的肺结节。进行了活检和随后的肺叶切除,以及广泛的转移性工作,这显示没有额外的质量。通过免疫组织化学染色未发现特定的分化线,基于RNA的融合小组显示了MEIS1::NCOA2融合,此时诊断为MEIS1::NCOA2-重排低度未分化肉瘤。
结论:该报告代表了原发性肺肿瘤的首次诊断,并提供了对这些罕见肿瘤的起源和定位的额外见解。