PDF(Pubmed)
Abstract：
BACKGROUND: Mitochondria dysfunction is one of the major causes of insulin resistance, and other countless complications of obesity. PGC-1α, and UCP-2 play key roles in energy expenditure regulation in the mitochondrial thermogenesis. However, the effects of bariatric surgery on the level of PGC-1α and UCP-2 and their relationships are unclear.
OBJECTIVE: This study aimed to investigate the effect of bariatric surgery on key pathways in energy, and to assess the potential predictive role of body composition and metabolic parameters in this regard.
METHODS: Hazrat-e Rasool General Hospital, Center of Excellence of International Federation for Surgery of Obesity.
METHODS: This prospective cohort study was carried out on 45 patients with morbid obesity who underwent Roux-en-Y gastric bypass surgery. The patients have evaluated three-time points at baseline, three, and six months after the surgery. Body composition components, the levels of PGC-1α, UCP-2, and metabolic parameters were measured three times during this study.
RESULTS: Significant changes in TWL%, EBMIL%, and metabolic lab tests were observed at three- and six months post-surgery (P < 0.001). The PGC-1α and UCP-2 had a significant increase three and then six-month post-operation compared with the baseline (P < 0.001). Moreover, multivariate linear regression analysis identified that the changing trend of PGC-1α was associated with insulin, uric Acid, HOMA-IR, fat mass and trunk fat mass. UCP-2 was associated with TSH, AST, fat mass and FFM.
CONCLUSIONS: Bariatric surgery has been shown to have a positive effect on UCP-2 and PGC-1α levels, as well as body composition and metabolic parameters. As a result, it is believed that bariatric surgery could improve thermogenesis and energy expenditure by enhancing mitochondrial biogenesis and function. However, further studies are needed to fully understand the precise mechanisms and possible causal relationship.
OBJECTIVE: This study aimed to investigate the effect of bariatric surgery on key pathways in energy, and to assess the potential predictive role of body composition and metabolic parameters in this regard.
METHODS: Hazrat-e Rasool General Hospital, Center of Excellence of International Federation for Surgery of Obesity.
METHODS: This prospective cohort study was carried out on 45 patients with morbid obesity who underwent Roux-en-Y gastric bypass surgery. The patients have evaluated three-time points at baseline, three, and six months after the surgery. Body composition components, the levels of PGC-1α, UCP-2, and metabolic parameters were measured three times during this study.
RESULTS: Significant changes in TWL%, EBMIL%, and metabolic lab tests were observed at three- and six months post-surgery (P < 0.001). The PGC-1α and UCP-2 had a significant increase three and then six-month post-operation compared with the baseline (P < 0.001). Moreover, multivariate linear regression analysis identified that the changing trend of PGC-1α was associated with insulin, uric Acid, HOMA-IR, fat mass and trunk fat mass. UCP-2 was associated with TSH, AST, fat mass and FFM.
CONCLUSIONS: Bariatric surgery has been shown to have a positive effect on UCP-2 and PGC-1α levels, as well as body composition and metabolic parameters. As a result, it is believed that bariatric surgery could improve thermogenesis and energy expenditure by enhancing mitochondrial biogenesis and function. However, further studies are needed to fully understand the precise mechanisms and possible causal relationship.
摘要：
背景：线粒体功能障碍是胰岛素抵抗的主要原因之一，和其他无数的肥胖并发症。PGC-1α,UCP-2在线粒体产热的能量消耗调节中起关键作用。然而,减肥手术对PGC-1α和UCP-2水平的影响及其相互关系尚不清楚.
目的：本研究旨在探讨减肥手术对能量，并评估身体成分和代谢参数在这方面的潜在预测作用。
方法：Hazrat-eRasool总医院，国际肥胖症外科联合会卓越中心。
方法：这项前瞻性队列研究对45例病态肥胖患者进行了Roux-en-Y胃旁路手术。患者在基线时评估了三个时间点，三,手术后六个月.身体成分成分，PGC-1α的水平，在本研究期间测量UCP-2和代谢参数三次。
结果：TWL%的显著变化，EBMIL%,术后3个月和6个月观察到代谢实验室检查（P<0.001）。与基线相比，PGC-1α和UCP-2在术后3个月和6个月有显着增加（P<0.001）。此外，多元线性回归分析发现PGC-1α的变化趋势与胰岛素,尿酸,HOMA-IR,脂肪量和躯干脂肪量。UCP-2与TSH相关,AST,脂肪量和FFM。
结论：减肥手术已被证明对UCP-2和PGC-1α水平有积极影响，以及身体成分和代谢参数。因此,人们认为减肥手术可以通过增强线粒体的生物发生和功能来改善产热和能量消耗。然而,需要进一步的研究来充分了解确切的机制和可能的因果关系。
目的：本研究旨在探讨减肥手术对能量，并评估身体成分和代谢参数在这方面的潜在预测作用。
方法：Hazrat-eRasool总医院，国际肥胖症外科联合会卓越中心。
方法：这项前瞻性队列研究对45例病态肥胖患者进行了Roux-en-Y胃旁路手术。患者在基线时评估了三个时间点，三,手术后六个月.身体成分成分，PGC-1α的水平，在本研究期间测量UCP-2和代谢参数三次。
结果：TWL%的显著变化，EBMIL%,术后3个月和6个月观察到代谢实验室检查（P<0.001）。与基线相比，PGC-1α和UCP-2在术后3个月和6个月有显着增加（P<0.001）。此外，多元线性回归分析发现PGC-1α的变化趋势与胰岛素,尿酸,HOMA-IR,脂肪量和躯干脂肪量。UCP-2与TSH相关,AST,脂肪量和FFM。
结论：减肥手术已被证明对UCP-2和PGC-1α水平有积极影响，以及身体成分和代谢参数。因此,人们认为减肥手术可以通过增强线粒体的生物发生和功能来改善产热和能量消耗。然而,需要进一步的研究来充分了解确切的机制和可能的因果关系。
