PDF(Pubmed)
Abstract：
BACKGROUND: Asthma is one of the most common chronic airway diseases in children. Preventing asthma exacerbation is one of the objectives of all asthma action plans. In patients with poor perception, it is difficult to identify acute asthma exacerbations by clinical asthma score, asthma control test or asthma control questionnaire. The aim of this study is to analyze whether children with asthma have changes in peak expiratory flow(PEF)before an acute asthma exacerbation and to evaluate the relationship between PEF and asthma exacerbation.
METHODS: Basic information (including sex, age, atopy, etc.) and clinical information of asthmatic children who registered in the Electronic China Children\'s Asthma Action Plan (e-CCAAP) from 1 September 2017 to 31 August 2021 were collected. Subjects with 14 consecutive days of PEF measurements were eligible. Subjects in this study were divided into an exacerbation group and a control group. We analyzed the relationship between changes in PEF% pred and the presence of asthma symptoms.
RESULTS: A total of 194 children with asthma who met the inclusion criteria were included, including 144 males (74.2%) and 50 females (25.8%), with a male-to-female ratio of 2.88:1. The mean age of the subjects was 9.51 ± 2.5 years. There were no significant differences in sex, age, allergy history or baseline PEF between the two groups. In children with and without a history of allergy, there was no significant difference between the variation in PEF at 14 days. Patients who only had a reduced in PEF but no symptoms of asthma exacerbation had the greatest reduction in PEF compared to the other groups. The most common cause of acute exacerbations of asthma is upper respiratory tract infection. Among the causes of acute exacerbations of asthma, the variation in PEF caused by air pollution was significantly higher than that of other causes (P < 0.05). In acute exacerbations, the decrease in PEF was significantly greater in the exacerbation group than in the control group. In children with asthma symptoms, there was a decrease in PEF approximately 1.34 days before the onset of symptoms.
CONCLUSIONS: Children with asthma show a decrease in PEF 1.34 days before the onset of asthma symptoms. We recommend that asthmatic children who show a decrease in PEF should step-up asthma therapy. The most common cause of acute exacerbations of asthma was upper respiratory tract infections, and the variation in PEF caused by air pollution was significantly higher than that caused by other factors.
METHODS: Basic information (including sex, age, atopy, etc.) and clinical information of asthmatic children who registered in the Electronic China Children\'s Asthma Action Plan (e-CCAAP) from 1 September 2017 to 31 August 2021 were collected. Subjects with 14 consecutive days of PEF measurements were eligible. Subjects in this study were divided into an exacerbation group and a control group. We analyzed the relationship between changes in PEF% pred and the presence of asthma symptoms.
RESULTS: A total of 194 children with asthma who met the inclusion criteria were included, including 144 males (74.2%) and 50 females (25.8%), with a male-to-female ratio of 2.88:1. The mean age of the subjects was 9.51 ± 2.5 years. There were no significant differences in sex, age, allergy history or baseline PEF between the two groups. In children with and without a history of allergy, there was no significant difference between the variation in PEF at 14 days. Patients who only had a reduced in PEF but no symptoms of asthma exacerbation had the greatest reduction in PEF compared to the other groups. The most common cause of acute exacerbations of asthma is upper respiratory tract infection. Among the causes of acute exacerbations of asthma, the variation in PEF caused by air pollution was significantly higher than that of other causes (P < 0.05). In acute exacerbations, the decrease in PEF was significantly greater in the exacerbation group than in the control group. In children with asthma symptoms, there was a decrease in PEF approximately 1.34 days before the onset of symptoms.
CONCLUSIONS: Children with asthma show a decrease in PEF 1.34 days before the onset of asthma symptoms. We recommend that asthmatic children who show a decrease in PEF should step-up asthma therapy. The most common cause of acute exacerbations of asthma was upper respiratory tract infections, and the variation in PEF caused by air pollution was significantly higher than that caused by other factors.
摘要：
背景：哮喘是儿童最常见的慢性气道疾病之一。预防哮喘加重是所有哮喘行动计划的目标之一。在感知不良的患者中，通过临床哮喘评分很难确定哮喘急性发作，哮喘控制测试或哮喘控制问卷。这项研究的目的是分析哮喘儿童在急性哮喘发作前是否有峰值呼气流量（PEF）的变化，并评估PEF与哮喘发作之间的关系。
方法：基本信息（包括性别，年龄,atopy,等。）和从2017年9月1日至2021年8月31日在电子中国儿童哮喘行动计划（e-CCAAP）中注册的哮喘儿童的临床信息。具有连续14天的PEF测量的受试者是合格的。本研究中的受试者被分为恶化组和对照组。我们分析了PEF%pred的变化与哮喘症状的存在之间的关系。
结果：共纳入194名符合纳入标准的哮喘患儿，其中男性144人(74.2%),女性50人(25.8%),男女比例为2.88:1。受试者的平均年龄为9.51±2.5岁。性别没有显著差异,年龄,两组之间的过敏史或基线PEF。在有和没有过敏史的儿童中，第14天PEF的变化之间没有显着差异。与其他组相比，仅PEF降低但无哮喘加重症状的患者PEF降低最大。哮喘急性发作的最常见原因是上呼吸道感染。在哮喘急性发作的原因中，空气污染引起的PEF变化明显高于其他原因（P<0.05）。急性加重时,恶化组的PEF下降幅度显著大于对照组.在有哮喘症状的儿童中，在症状出现前约1.34天,PEF降低.
结论：哮喘患儿在哮喘症状发作前1.34天出现PEF下降。我们建议PEF减少的哮喘儿童应加强哮喘治疗。哮喘急性发作的最常见原因是上呼吸道感染，空气污染引起的PEF变化明显高于其他因素。
方法：基本信息（包括性别，年龄,atopy,等。）和从2017年9月1日至2021年8月31日在电子中国儿童哮喘行动计划（e-CCAAP）中注册的哮喘儿童的临床信息。具有连续14天的PEF测量的受试者是合格的。本研究中的受试者被分为恶化组和对照组。我们分析了PEF%pred的变化与哮喘症状的存在之间的关系。
结果：共纳入194名符合纳入标准的哮喘患儿，其中男性144人(74.2%),女性50人(25.8%),男女比例为2.88:1。受试者的平均年龄为9.51±2.5岁。性别没有显著差异,年龄,两组之间的过敏史或基线PEF。在有和没有过敏史的儿童中，第14天PEF的变化之间没有显着差异。与其他组相比，仅PEF降低但无哮喘加重症状的患者PEF降低最大。哮喘急性发作的最常见原因是上呼吸道感染。在哮喘急性发作的原因中，空气污染引起的PEF变化明显高于其他原因（P<0.05）。急性加重时,恶化组的PEF下降幅度显著大于对照组.在有哮喘症状的儿童中，在症状出现前约1.34天,PEF降低.
结论：哮喘患儿在哮喘症状发作前1.34天出现PEF下降。我们建议PEF减少的哮喘儿童应加强哮喘治疗。哮喘急性发作的最常见原因是上呼吸道感染，空气污染引起的PEF变化明显高于其他因素。
