Abstract：
Hookworms are parasites, closely related to the model nematode Caenorhabditis elegans, that are a major economic and health burden worldwide. Primarily three hookworm species (Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum) infect humans. Another 100 hookworm species from 19 genera infect primates, ruminants, and carnivores. Genetic data exist for only seven of these species. Genome sequences are available from only four of these species in two genera, leaving 96 others (particularly those parasitizing wildlife) without any genomic data. The most recent hookworm genomes were published 5 years ago, leaving the field in a dusk. However, assembling genomes from single hookworms may bring a new dawn. Here we summarize advances, challenges, and opportunities for studying these neglected but important parasitic nematodes.
摘要：
钩虫是寄生虫,与线虫模型密切相关的秀丽隐杆线虫，这是全世界的重大经济和健康负担。主要有三种钩虫（Necatoramericanus，十二指肠囊肿,Ancylostomaceylanicum）感染人类。来自19属的另外100种钩虫感染灵长类动物，反刍动物,和食肉动物。这些物种中只有7种存在遗传数据。基因组序列只能从两个属中的四个物种获得，剩下96个（特别是那些寄生野生动物）没有任何基因组数据。最近的钩虫基因组发表于5年前,黄昏离开田野.然而,从单个钩虫组装基因组可能会带来新的曙光。在这里，我们总结了进展，挑战,以及研究这些被忽视但重要的寄生线虫的机会。
