Abstract：
Combining the versatility of electrospinning with the biocompatibility of Polycaprolactone and Collagen, this study aims to create advanced 3D nano scaffolds for effective drug delivery. Ceramic materials like hydroxyapatite (nHAp) are incorporated as bioactive agents in the fibers. Electrospun PCL (Polycaprolactone)/collagen nanofibers and PVA (Poly-vinyl alcohol)/collagen are promising tissue-engineering substitutes with high biocompatibility, low cytotoxicity, and great tensile strength. Small pores in these nanofibers play a major role in drug delivery system. Owing to its short half-life, limited solubility, restricted bioavailability as well as re-crystallization concerns, the application of Cetirizine (CIT) has found little relevance. Electrospun nanofibers impregnated with CIT provide an excellent solution to combat these limitations, yield sustained drug release along with hampering drug re-crystallization. CIT-loaded polyvinyl alcohol (PVA)/collagen (Col) and CIT-loaded PVA/Col/nHAp nanofibers were characterized and further CIT anti-crystallization as well as release behaviors were investigated. FESEM and HRTEM were used to observe the morphology of the as-synthesized nanofibers. FTIR spectroscopy, water contact angle measurement and drug release studies verified the differences in performance of CIT-loaded PVA/Col and PVA/Col/nHAp nanofibers. The release trend of CIT through these as-synthesized nanoscaffolds was analyzed by various kinetic models and exhibited sustained release of CIT for up to 96 h.
摘要：
将静电纺丝的多功能性与聚己内酯和胶原蛋白的生物相容性相结合，本研究旨在创造先进的3D纳米支架，用于有效的药物输送。将陶瓷材料如羟基磷灰石(nHAp)作为生物活性剂掺入纤维中。静电纺PCL（聚己内酯）/胶原纳米纤维和PVA（聚乙烯醇）/胶原是具有高生物相容性的组织工程替代品，低细胞毒性，和巨大的抗拉强度。这些纳米纤维中的小孔在药物递送系统中起主要作用。由于其半衰期短，有限的溶解度，限制生物利用度以及重结晶问题，西替利嗪（CIT）的应用几乎没有相关性。电纺纳米纤维浸渍CIT提供了一个很好的解决方案，以克服这些限制，产生持续的药物释放以及阻碍药物重结晶。对CIT负载的聚乙烯醇（PVA）/胶原蛋白（Col）和CIT负载的PVA/Col/nHAp纳米纤维进行了表征，并进一步研究了CIT的抗结晶和释放行为。使用FESEM和HRTEM观察合成的纳米纤维的形态。FTIR光谱,水接触角测量和药物释放研究验证了CIT负载的PVA/Col和PVA/Col/nHAp纳米纤维的性能差异。通过各种动力学模型分析了CIT通过这些合成的纳米支架的释放趋势，并表现出CIT的持续释放长达96小时。
