Abstract：
OBJECTIVE: To compare quantitative tortuosity descriptors of Internal Carotid Artery (ICA) on aneurysmal and non-aneurysmal side before and after embolization of aneurysm and to determine possible factors associated with its change.
METHODS: An analysis of 52 patients with intracranial aneurysm, treated with endovascular procedure, was performed. Based on their Digital Subtraction Angiography images, obtained prior to the procedure and after first follow-up examination, tortuosity of ICA, both on the side of embolization and on the other side was analysed. For each patient tortuosity descriptors were calculated: Relative Length, Sum of Angle Metrics, Triangular Index, Product of Angle Distance, and Inflection Count Metric. To represent changes in tortuosity, for each descriptor delta value (Δ) was defined as value of the descriptor prior to embolization - value of the descriptor on follow-up examination.
RESULTS: In the follow-up We found no statistically significant changes in tortuosity on non-embolized side. On the embolized side SOAM (2.89±0.92 vs. 2.38±0.94;p<0.001), PAD (5.01±1.83 vs. 3.95±1.72 ;p<0.001) and ICM (12.18±4.55 vs. 9.76±4.04 vs.;p = 0.006) was significantly higher after embolization than before embolization. Mean ΔRelative Length (-0.02 [-0.045--0.002] vs. -0.01 [-0.02-0.003];p - 0.003),ΔProduct of Angle Distance (0.84 [0.30 - 1.82] vs. 0.10 [-0.001 - 1.10];p<0.001) and ΔInflection Count Metric (2.05 [0.42 - 3.50] vs. 0.27 [0.02 - 2.16];p = 0.004) were significantly higher on the embolized side.
CONCLUSIONS: Following study showed that embolization may increase the tortuosity of ICA.
METHODS: An analysis of 52 patients with intracranial aneurysm, treated with endovascular procedure, was performed. Based on their Digital Subtraction Angiography images, obtained prior to the procedure and after first follow-up examination, tortuosity of ICA, both on the side of embolization and on the other side was analysed. For each patient tortuosity descriptors were calculated: Relative Length, Sum of Angle Metrics, Triangular Index, Product of Angle Distance, and Inflection Count Metric. To represent changes in tortuosity, for each descriptor delta value (Δ) was defined as value of the descriptor prior to embolization - value of the descriptor on follow-up examination.
RESULTS: In the follow-up We found no statistically significant changes in tortuosity on non-embolized side. On the embolized side SOAM (2.89±0.92 vs. 2.38±0.94;p<0.001), PAD (5.01±1.83 vs. 3.95±1.72 ;p<0.001) and ICM (12.18±4.55 vs. 9.76±4.04 vs.;p = 0.006) was significantly higher after embolization than before embolization. Mean ΔRelative Length (-0.02 [-0.045--0.002] vs. -0.01 [-0.02-0.003];p - 0.003),ΔProduct of Angle Distance (0.84 [0.30 - 1.82] vs. 0.10 [-0.001 - 1.10];p<0.001) and ΔInflection Count Metric (2.05 [0.42 - 3.50] vs. 0.27 [0.02 - 2.16];p = 0.004) were significantly higher on the embolized side.
CONCLUSIONS: Following study showed that embolization may increase the tortuosity of ICA.
摘要：
目的：比较动脉瘤栓塞前后动脉瘤侧和非动脉瘤侧颈内动脉（ICA）的定量弯曲度，并确定与其变化相关的可能因素。
方法：分析52例颅内动脉瘤患者，用血管内手术治疗，已执行。根据他们的数字减影血管造影图像，在手术前和第一次随访检查后获得，ICA的弯曲，分析了栓塞一侧和另一侧。计算每位患者的弯曲度描述符：相对长度，角度度量的总和,三角形索引,角距离的乘积,和拐点计数度量。为了表示弯曲度的变化，每个描述符的delta值(Δ)定义为栓塞前描述符的值-随访检查中描述符的值.
结果：在随访中，我们未发现非栓塞侧的弯曲没有统计学上的显着变化。在栓塞侧SOAM（2.89±0.92vs.2.38±0.94；p<0.001)，PAD(5.01±1.83vs.3.95±1.72；p<0.001）和ICM（12.18±4.55vs.9.76±4.04vs.；p=0.006）栓塞后明显高于栓塞前。平均Δ相对长度(-0.02[-0.045--0.002]与-0.01[-0.02-0.003]；p-0.003），角距离的Δ乘积(0.84[0.30-1.82]与0.10[-0.001-1.10]；p<0.001）和Δ拐点计数度量（2.05[0.42-3.50]与0.27[0.02-2.16]；p=0.004）在栓塞侧明显更高。
结论：以下研究表明栓塞可能会增加ICA的弯曲度。
方法：分析52例颅内动脉瘤患者，用血管内手术治疗，已执行。根据他们的数字减影血管造影图像，在手术前和第一次随访检查后获得，ICA的弯曲，分析了栓塞一侧和另一侧。计算每位患者的弯曲度描述符：相对长度，角度度量的总和,三角形索引,角距离的乘积,和拐点计数度量。为了表示弯曲度的变化，每个描述符的delta值(Δ)定义为栓塞前描述符的值-随访检查中描述符的值.
结果：在随访中，我们未发现非栓塞侧的弯曲没有统计学上的显着变化。在栓塞侧SOAM（2.89±0.92vs.2.38±0.94；p<0.001)，PAD(5.01±1.83vs.3.95±1.72；p<0.001）和ICM（12.18±4.55vs.9.76±4.04vs.；p=0.006）栓塞后明显高于栓塞前。平均Δ相对长度(-0.02[-0.045--0.002]与-0.01[-0.02-0.003]；p-0.003），角距离的Δ乘积(0.84[0.30-1.82]与0.10[-0.001-1.10]；p<0.001）和Δ拐点计数度量（2.05[0.42-3.50]与0.27[0.02-2.16]；p=0.004）在栓塞侧明显更高。
结论：以下研究表明栓塞可能会增加ICA的弯曲度。
