关键词: Asthenozoospermia Male infertility STYXL1 Tubulin

Mesh : Male Humans Infertility, Male / genetics pathology Sperm Motility / genetics Spermatozoa Sperm Tail / pathology metabolism Microtubules / genetics metabolism

来  源:   DOI:10.1007/s10815-024-03122-9   PDF(Pubmed)

Abstract:
In a recent journal article, Chen et al. identified a germ cell-specific cofactor, STYXL1, associated with male fertility function. Deletion of STYXL1 prevents the LEGO player CCT complex from properly folding key microtubule proteins of the sperm flagellum, which affects sperm motility and male fertility function.
摘要:
在最近的一篇期刊文章中,Chenetal.确定了生殖细胞特异性辅因子,STYXL1,与男性生育功能相关。STYXL1的缺失可防止乐高播放器CCT复合物正确折叠精子鞭毛的关键微管蛋白,影响精子活力和男性生育功能。
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