PDF(Pubmed)
Abstract：
BACKGROUND: This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer\'s disease (AD) biomarkers, and cognition.
METHODS: Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.
RESULTS: LA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or posterior wall thickness and ventricular mass) were associated with higher CSF phosphorylated (p)-tau and total (t)-tau levels, and poorer cognition. Tau pathologies mediated the heart-cognition relationships. Cardiac parameters were higher in stage 2 and suspected non-Alzheimer\'s pathology groups than controls.
CONCLUSIONS: These findings suggested close associations of subclinical cardiac changes with tau pathologies and cognition.
CONCLUSIONS: Various subclinical alterations in the left heart related to poorer cognition. Subclinical cardiac changes related to tau pathologies in cognitively normal adults. Tau pathologies mediated the heart-cognition relationships. Subclinical cardiac changes related to the AD continuum, especially to stage 2. The accumulation of cardiac alterations magnified their damage to the brain.
METHODS: Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.
RESULTS: LA or LV enlargement (characterized by increased diameters and volumes) and LV hypertrophy (increased interventricular septal or posterior wall thickness and ventricular mass) were associated with higher CSF phosphorylated (p)-tau and total (t)-tau levels, and poorer cognition. Tau pathologies mediated the heart-cognition relationships. Cardiac parameters were higher in stage 2 and suspected non-Alzheimer\'s pathology groups than controls.
CONCLUSIONS: These findings suggested close associations of subclinical cardiac changes with tau pathologies and cognition.
CONCLUSIONS: Various subclinical alterations in the left heart related to poorer cognition. Subclinical cardiac changes related to tau pathologies in cognitively normal adults. Tau pathologies mediated the heart-cognition relationships. Subclinical cardiac changes related to the AD continuum, especially to stage 2. The accumulation of cardiac alterations magnified their damage to the brain.
摘要：
背景：这项研究描述了左心亚临床改变之间的相互关系，脑脊液（CSF），阿尔茨海默病（AD）生物标志物，和认知。
方法：对1244名认知正常的参与者（平均年龄为65.5岁；43%为女性）进行了超声心动图（左心房[LA]和左心室[LV]形态或功能参数）和CSFAD生物标志物测量，进行了多重线性回归分析。检查了AD病理的中介作用。使用方差分析（ANOVA）和逻辑回归分析测试了ATN类别中心脏参数的差异。
结果：LA或LV增大（以直径和体积增加为特征）和LV肥大（室间隔或后壁厚度和心室质量增加）与较高的CSF磷酸化（p）-tau和总（t）-tau水平相关。认知能力较差。Tau病理学介导了心脏-认知关系。2期和疑似非阿尔茨海默病病理组的心脏参数高于对照组。
结论：这些发现提示亚临床心脏改变与tau病理和认知密切相关。
结论：左心的各种亚临床改变与较差的认知有关。认知正常成年人中与tau病理相关的亚临床心脏变化。Tau病理学介导了心脏-认知关系。与AD连续性相关的亚临床心脏变化，尤其是第二阶段。心脏改变的积累放大了它们对大脑的损害。
方法：对1244名认知正常的参与者（平均年龄为65.5岁；43%为女性）进行了超声心动图（左心房[LA]和左心室[LV]形态或功能参数）和CSFAD生物标志物测量，进行了多重线性回归分析。检查了AD病理的中介作用。使用方差分析（ANOVA）和逻辑回归分析测试了ATN类别中心脏参数的差异。
结果：LA或LV增大（以直径和体积增加为特征）和LV肥大（室间隔或后壁厚度和心室质量增加）与较高的CSF磷酸化（p）-tau和总（t）-tau水平相关。认知能力较差。Tau病理学介导了心脏-认知关系。2期和疑似非阿尔茨海默病病理组的心脏参数高于对照组。
结论：这些发现提示亚临床心脏改变与tau病理和认知密切相关。
结论：左心的各种亚临床改变与较差的认知有关。认知正常成年人中与tau病理相关的亚临床心脏变化。Tau病理学介导了心脏-认知关系。与AD连续性相关的亚临床心脏变化，尤其是第二阶段。心脏改变的积累放大了它们对大脑的损害。
