PDF(Pubmed)
Abstract：
Reverse zoonotic transmission events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described since the start of the pandemic, and the World Organisation for Animal Health (WOAH) designated the detection of SARS-CoV-2 in animals a reportable disease. Eighteen domestic and zoo animals in Great Britain and Jersey were tested by APHA for SARS-CoV-2 during 2020-2023. One domestic cat (Felis catus), three domestic dogs (Canis lupus familiaris), and three Amur tigers (Panthera tigris altaica) from a zoo were confirmed positive during 2020-2021 and reported to the WOAH. All seven positive animals were linked with known SARS-CoV-2 positive human contacts. Characterisation of the SARS-CoV-2 variants by genome sequencing indicated that the cat was infected with an early SARS-CoV-2 lineage. The three dogs and three tigers were infected with the SARS-CoV-2 Delta variant of concern (B.1.617.2). The role of non-human species in the onward transmission and emergence of new variants of SARS-CoV-2 remain poorly defined. Continued surveillance of SARS-CoV-2 in relevant domestic and captive animal species with high levels of human contact is important to monitor transmission at the human-animal interface and to assess their role as potential animal reservoirs.
摘要：
自大流行开始以来，已经描述了严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）的反向人畜共患病传播事件，世界动物卫生组织（WOAH）指定在动物中检测SARS-CoV-2是一种可报告的疾病。在2020-2023年期间，APHA对英国和泽西岛的18只家养和动物园动物进行了SARS-CoV-2测试。一只家猫（Feliscatus），三只家犬（犬狼疮），来自动物园的三只阿穆尔虎（Pantheratigrisaltaica）在2020-2021年期间被确认为阳性，并报告给了WOAH。所有七只阳性动物都与已知的SARS-CoV-2阳性人类接触有关。通过基因组测序对SARS-CoV-2变体的表征表明该猫感染了早期的SARS-CoV-2谱系。三只狗和三只老虎感染了受关注的SARS-CoV-2Delta变体（B.1.617.2）。非人类物种在SARS-CoV-2新变体的传播和出现中的作用仍然不明确。在与人接触程度高的相关家养和圈养动物物种中持续监测SARS-CoV-2对于监测人-动物界面的传播并评估其作为潜在动物宿主的作用非常重要。
