PDF(Pubmed)
Abstract：
Long coronavirus disease (COVID) syndrome leads to chronic inflammatory state onset that can have a multisystem impact and compromise organ function. Moreover, long COVID syndrome is often characterized by the presence of chronic fatigue, which affects subjects\' daily activities and worsens their quality of life. The aim of our double-blind, placebo-controlled randomized trial (protocol code RS 150.21, approved on 4 November 2021) was to evaluate the beneficial effects of the consumption of 2 cps/day, for two months, of an oral food supplement (OFS), based on Echinacea angustifolia, rosehip, propolis, royal jelly and zinc, in long COVID patients, compared to a two-month placebo period. The OFS\'s vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS\'s total polyphenol content was 43.98 mg/g gallic acid equivalents. At the end of the in vivo study, we highlighted a significant decrease in the inflammatory parameters in the OFS period, compared to the placebo period (neutrophil-to-lymphocyte ratio, p = 0.0455; monocyte to-lymphocyte ratio, p = 0.0005; C-reactive protein, p = 0.0145). Our study also highlighted a significant increase in vitamin D serum values (p = 0.0005) and, at the same time, an improvement in patients\' life quality and a reduction in fatigue, monitored by the fatigue severity scale. This study showed the OFS\'s beneficial effects on the inflammatory state, fatigue and quality of life in long COVID patients.
摘要：
长冠状病毒病(COVID)综合征导致慢性炎症状态发作，可能产生多系统影响并损害器官功能。此外，长COVID综合征的特征通常是存在慢性疲劳，这会影响受试者的日常活动并恶化他们的生活质量。我们双盲的目标，安慰剂对照随机试验（方案代码RS150.21，2021年11月4日批准）是为了评估2cps/天的消费的有益效果，两个月,口服食品补充剂(OFS)，基于紫锥菊，玫瑰果,蜂胶,蜂王浆和锌，在长期的COVID患者中，与两个月的安慰剂期相比。OFS的维生素C含量等于22.17mg/g（8.87mg/胶囊）。OFS的总多酚含量为43.98mg/g没食子酸当量。在体内研究结束时，我们强调了OFS期间炎症参数的显着下降，与安慰剂期相比(中性粒细胞与淋巴细胞的比率，p=0.0455；单核细胞与淋巴细胞的比率，p=0.0005;C反应蛋白,p=0.0145）。我们的研究还强调了维生素D血清值的显着增加（p=0.0005），同时,改善患者的生活质量和减少疲劳，通过疲劳严重程度量表监测。这项研究表明OFS对炎症状态的有益作用，长期COVID患者的疲劳和生活质量。
