PDF(Pubmed)
Abstract：
Arterial stiffness has been proved to be an important parameter in the evaluation of cardiovascular diseases, and Pulse Wave Velocity (PWV) is a strong indicator of arterial stiffness. Compared to regional PWV (PWV among different arteries), local PWV (PWV within a single artery) outstands in providing higher precision in indicating arterial properties, as regional PWVs are highly affected by multiple parameters, e.g., variations in blood vessel lengths due to individual differences, and multiple reflection effects on the pulse waveform. However, local PWV is less-developed due to its high dependency on the temporal resolution in synchronized signals with usually low signal-to-noise ratios. This paper presents a method for the noninvasive simultaneous measurement of two local PWVs in both left and right radial arteries based on the Fiber Bragg Grating (FBG) technique via correlation analysis of the pulse pairs at the fossa cubitalis and at the wrist. Based on the measurements of five male volunteers at the ages of 19 to 21 years old, the average left radial PWV ranged from 9.44 m/s to 12.35 m/s and the average right radial PWV ranged from 11.50 m/s to 14.83 m/s. What is worth mentioning is that a stable difference between the left and right radial PWVs was observed for each volunteer, ranging from 2.27 m/s to 3.04 m/s. This method enables the dynamic analysis of local PWVs and analysis of their features among different arteries, which will benefit the diagnosis of early-stage arterial stiffening and may bring more insights into the diagnosis of cardiovascular diseases.
摘要：
动脉僵硬度已被证明是评价心血管疾病的重要参数。脉搏波速度（PWV）是动脉僵硬度的重要指标。与区域PWV（不同动脉之间的PWV）相比，局部PWV（单支动脉内的PWV）在指示动脉特性方面提供了更高的精度，由于区域PWV受到多个参数的高度影响，例如，由于个体差异，血管长度的变化，和对脉冲波形的多重反射效应。然而,由于局部PWV对同步信号的时间分辨率的高度依赖性，通常信噪比较低。本文提出了一种基于光纤布拉格光栅（FBG）技术，通过对肘窝和腕部的脉冲对的相关性分析，对左右桡动脉中的两个局部PWV进行无创同时测量的方法。根据对五名19至21岁男性志愿者的测量，平均左径向PWV范围为9.44m/s至12.35m/s，平均右径向PWV范围为11.50m/s至14.83m/s。值得一提的是，每个志愿者的左右径向PWV之间观察到稳定的差异，范围从2.27m/s到3.04m/s。该方法可以对局部PWV进行动态分析，并分析其在不同动脉之间的特征，这将有利于早期动脉硬化的诊断，并可能为心血管疾病的诊断带来更多的见解。
