PDF(Pubmed)
Abstract：
Fat synthesis and lipolysis are natural processes in growth and have a close association with health. Fat provides energy, maintains physiological function, and so on, and thus plays a significant role in the body. However, excessive/abnormal fat accumulation leads to obesity and lipid metabolism disorder, which can have a detrimental impact on growth and even harm one\'s health. Aside from genetic effects, there are a range of factors related to obesity, such as excessive nutrient intake, inflammation, glycometabolism disease, and so on. These factors could serve as potential targets for anti-obesity therapy. Quercetin is a flavonol that has received a lot of attention recently because of its role in anti-obesity. It was thought to have the ability to regulate lipid metabolism and have a positive effect on anti-obesity, but the processes are still unknown. Recent studies have shown the role of quercetin in lipid metabolism might be related to its effects on inflammatory responses and glycometabolism. The references were chosen for this review with no date restrictions applied based on the topics they addressed, and the databases PubMed and Web of Sicence was used to conduct the references research, using the following search terms: \"quercetin\", \"obesity\", \"inflammation\", \"glycometabolism\", \"insulin sensitivity\", etc. This review summarizes the potential mechanisms of quercetin in alleviating lipid metabolism through anti-inflammatory and hypoglycemic signaling pathways, and describes the possible signaling pathways in the interaction of inflammation and glycometabolism, with the goal of providing references for future research and application of quercetin in the regulation of lipid metabolism.
摘要：
脂肪合成和脂肪分解是生长的自然过程，与健康密切相关。脂肪提供能量，维持生理功能，等等，因此在身体中起着重要的作用。然而,过度/异常脂肪积累导致肥胖和脂质代谢紊乱，这会对生长产生有害影响，甚至损害人的健康。除了遗传影响,有一系列与肥胖有关的因素，如过量的营养摄入，炎症,糖代谢疾病，等等。这些因素可以作为抗肥胖治疗的潜在目标。槲皮素是一种黄酮醇，由于其在抗肥胖中的作用，最近受到了很多关注。它被认为具有调节脂质代谢的能力，并对抗肥胖有积极作用，但是过程仍然未知。最近的研究表明槲皮素在脂质代谢中的作用可能与其对炎症反应和糖代谢的影响有关。本次审查选择了参考文献，但没有根据它们所涉及的主题应用日期限制，并利用PubMed和SicenceWeb数据库进行了参考研究，使用以下搜索词:\"quercetin\",“肥胖”，\"炎症\",“糖代谢”，“胰岛素敏感性”，等。本文综述了槲皮素通过抗炎和降糖信号通路缓解脂质代谢的潜在机制。并描述了炎症和糖代谢相互作用中可能的信号通路，以期为未来槲皮素在脂质代谢调控中的研究和应用提供参考。
