PDF(Pubmed)
Abstract：
Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and are an essential part of the innate immune system. Neutrophils are efficient cells that eliminate pathogenic bacteria and fungi, but their role in dealing with protozoan parasitic infections remains controversial. At sites of protozoan parasite infections, a large number of infiltrating neutrophils is observed, suggesting that neutrophils are important cells for controlling the infection. Yet, in most cases, there is also a strong inflammatory response that can provoke tissue damage. Diseases like malaria, trichomoniasis, leishmaniasis, Chagas disease, and amoebiasis affect millions of people globally. In this review, we summarize these protozoan diseases and describe the novel view on how neutrophils are involved in protection from these parasites. Also, we present recent evidence that neutrophils play a double role in these infections participating both in control of the parasite and in the pathogenesis of the disease.
摘要：
中性粒细胞是人类血液中最丰富的多形核颗粒白细胞，是先天免疫系统的重要组成部分。中性粒细胞是消灭致病菌和真菌的有效细胞,但是它们在处理原生动物寄生虫感染中的作用仍然存在争议。在原生动物寄生虫感染的部位，观察到大量浸润的中性粒细胞，表明中性粒细胞是控制感染的重要细胞。然而，在大多数情况下,也有强烈的炎症反应，可以引起组织损伤。像疟疾这样的疾病，滴虫病,利什曼病,查加斯病,变形虫病影响着全球数百万人。在这次审查中,我们总结了这些原生动物疾病，并描述了中性粒细胞如何参与保护免受这些寄生虫侵害的新观点。此外，我们提供了最近的证据，表明中性粒细胞在这些感染中发挥双重作用，参与寄生虫的控制和疾病的发病机制。
