PDF(Pubmed)
Abstract：
COVID-19 has been notoriously unpredictable in its clinical course. Such unpredictability poses a challenge to clinicians in predicting patients who will develop severe cases and possibly die from the infection. This study aims to assess and compare the diagnostic value of the NLR and SII as biomarkers in predicting COVID-19 severity, represented by mortality, with a multicentre comparative study including 855 patients in Saudi Arabia. Descriptive and analytical statistics were used to compare haematological indices between survivors and non-survivors. The median age of patients included was 41 years old, with an almost equal ratio of men to women. Most participants were Saudis, and the mortality rate in the study cohort was 13.22%. Non-survivors, as compared to survivors, were significantly older, had lower RBC counts, haemoglobin and haematocrit levels, as well as significantly higher WBC and neutrophil counts. Both the NLR and SII were capable of differentiating between survivors and non-survivors, with the latter having significantly higher values. However, the NLR was superior to the SII in such differentiation, as it had a larger area under the curve. This study further confirms the diagnostic values of the NLR and SII as biomarkers in predicting COVID-19 severity and mortality, with the NLR being more sensitive and specific. Clinical guidelines on managing COVID-19 cases should benefit from these findings by harnessing the value of the NLR in COVID-19 management.
摘要：
众所周知，COVID-19在其临床过程中是不可预测的。这种不可预测性对临床医生在预测将发展为严重病例并可能死于感染的患者方面提出了挑战。本研究旨在评估和比较NLR和SII作为预测COVID-19严重程度的生物标志物的诊断价值。以死亡率为代表，一项多中心比较研究，包括沙特阿拉伯的855名患者。使用描述性和分析性统计数据来比较幸存者和非幸存者之间的血液学指数。纳入患者的中位年龄为41岁，男女比例几乎相等。大多数参与者是沙特人，研究队列的死亡率为13.22%.非幸存者,与幸存者相比，明显更老，红细胞计数较低，血红蛋白和血细胞比容水平，以及显著较高的白细胞和中性粒细胞计数。NLR和SII都能够区分幸存者和非幸存者，后者具有明显更高的价值。然而,NLR在这种区分上优于SII，因为它在曲线下的面积更大。这项研究进一步证实了NLR和SII作为预测COVID-19严重程度和死亡率的生物标志物的诊断价值，NLR更加敏感和具体。通过利用NLR在COVID-19管理中的价值，管理COVID-19病例的临床指南应从这些发现中受益。
