PDF(Pubmed)
Abstract：
Mammalian melanin is produced in melanocytes and accumulated in melanosomes. Melanogenesis is supported by many factors derived from the surrounding tissue environment, such as the epidermis, dermis, and subcutaneous tissue, in addition to numerous melanogenesis-related genes. The roles of these genes have been fully investigated and the molecular analysis has been performed. Moreover, the role of paracrine factors derived from epidermis has also been studied. However, the role of dermis has not been fully studied. Thus, in this review, dermis-derived factors including soluble and insoluble components were overviewed and discussed in normal and abnormal circumstances. Dermal factors play an important role in the regulation of melanogenesis in the normal and abnormal mammalian skin.
摘要：
哺乳动物黑色素在黑素细胞中产生并在黑色素体中积累。黑变形成由周围组织环境的许多因素支持，比如表皮，真皮,和皮下组织，除了许多黑色素生成相关基因。已经充分研究了这些基因的作用并进行了分子分析。此外，来自表皮的旁分泌因子的作用也已被研究。然而,真皮的作用尚未得到充分研究。因此，在这次审查中,包括可溶性和不溶性成分在内的真皮衍生因子在正常和异常情况下进行了概述和讨论.在正常和异常哺乳动物皮肤中,皮肤因子在调节黑素生成中起重要作用。
