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Abstract：
To investigate the plasma lipoprotein subclasses in patients with primary open-angle glaucoma (POAG), a total of 20 Chinese POAG patients on intraocular pressure (IOP)-lowering treatment and 20 age-matched control subjects were recruited. Based on the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), the study subjects were divided into elevated- and normal-level subgroups. The plasma lipoprotein, lipoprotein subclasses, and oxidized LDL (oxLDL) levels were quantitatively measured. The discrimination potential of the lipoproteins was evaluated using the area under the receiver operating characteristic curve (AUC), and their correlation with clinical parameters was also evaluated. Compared to the control subjects with elevated TC and/or LDL-C levels, the levels of TC, LDL-C, non-high-density lipoprotein cholesterol (non-HDL), LDL subclass LDL3 and small dense LDL (sdLDL), and oxLDL were significantly higher in POAG patients with elevated TC and/or LDL-C levels. No differences in any lipoproteins or the subclasses were found between the POAG patients and control subjects with normal TC and LDL-C levels. Moderate-to-good performance of TC, LDL-C, non-HDL, LDL3, sdLDL, and oxLDL was found in discriminating between the POAG patients and control subjects with elevated TC and/or LDL-C levels (AUC: 0.710-0.950). Significant negative correlations between LDL3 and sdLDL with retinal nerve fiber layer (RNFL) thickness in the superior quadrant and between LDL3 and average RNFL thickness were observed in POAG patients with elevated TC and/or LDL-C levels. This study revealed a significant elevation of plasma lipoproteins, especially the LDL subclasses, in POAG patients with elevated TC and/or LDL-C levels, providing insights on monitoring specific lipoproteins in POAG patients with elevated TC and/or LDL-C.
摘要：
探讨原发性开角型青光眼(POAG)患者血浆脂蛋白亚类,我们共招募了20名接受降低眼压(IOP)治疗的中国POAG患者和20名年龄匹配的对照组.根据总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）的水平，研究对象分为升高水平和正常水平亚组.血浆脂蛋白，脂蛋白亚类，定量测量氧化LDL（oxLDL）水平。使用受试者工作特征曲线下面积（AUC）评估脂蛋白的区分潜力，并且还评估了它们与临床参数的相关性。与TC和/或LDL-C水平升高的对照受试者相比，TC的水平，LDL-C,非高密度脂蛋白胆固醇（非HDL），LDL亚类LDL3和小密LDL（sdLDL），在TC和/或LDL-C水平升高的POAG患者中，oxLDL和oxLDL显着升高。在POAG患者和TC和LDL-C水平正常的对照受试者之间没有发现任何脂蛋白或亚类的差异。TC的中佳表现，LDL-C,非HDL,LDL3,sdLDL,和oxLDL在POAG患者和TC和/或LDL-C水平升高的对照受试者之间存在区别(AUC:0.710-0.950)。在TC和/或LDL-C水平升高的POAG患者中，观察到LDL3和sdLDL与上象限的视网膜神经纤维层（RNFL）厚度以及LDL3与平均RNFL厚度之间呈显着负相关。这项研究揭示了血浆脂蛋白的显着升高，尤其是LDL亚类，在TC和/或LDL-C水平升高的POAG患者中，为监测TC和/或LDL-C升高的POAG患者的特异性脂蛋白提供见解。
