PDF(Pubmed)
Abstract：
Chromosomal instability (CIN), defined by variations in the number or structure of chromosomes from cell to cell, is recognized as a distinctive characteristic of cancer associated with the ability of tumors to adapt to challenging environments. CIN has been recognized as a source of genetic variation that leads to clonal heterogeneity (CH). Recent findings suggest a potential association between CIN and CH with the prognosis of BC patients, particularly in tumors expressing the epidermal growth factor receptor 2 (HER2+). In fact, information on the role of CIN in other BC subtypes, including luminal B BC, is limited. Additionally, it remains unknown whether CIN in luminal B BC tumors, above a specific threshold, could have a detrimental effect on the growth of human tumors or whether low or intermediate CIN levels could be linked to a more favorable BC patient prognosis when contrasted with elevated levels. Clarifying these relationships could have a substantial impact on risk stratification and the development of future therapeutic strategies aimed at targeting CIN in BC. This study aimed to assess CIN and CH in tumor tissue samples from ten patients with luminal B BC and compare them with established clinicopathological parameters. The results of this study reveal that luminal B BC patients exhibit intermediate CIN and stable aneuploidy, both of which correlate with lymphovascular invasion. Our results also provide valuable preliminary data that could contribute to the understanding of the implications of CIN and CH in risk stratification and the development of future therapeutic strategies in BC.
摘要：
染色体不稳定(CIN),由细胞间染色体数量或结构的变化定义，被认为是与肿瘤适应挑战性环境的能力相关的癌症的独特特征。CIN已被认为是导致克隆异质性（CH）的遗传变异的来源。最近的研究结果表明，CIN和CH与BC患者的预后之间存在潜在的关联。特别是在表达表皮生长因子受体2（HER2）的肿瘤中。事实上,有关CIN在其他BC亚型中的作用的信息，包括管腔BC，是有限的。此外,尚不清楚CIN是否在腔BBC肿瘤中，高于特定阈值，可能对人类肿瘤的生长产生不利影响，或者与升高的水平相比，低或中等的CIN水平是否与更有利的BC患者预后有关。澄清这些关系可能会对风险分层和未来针对BC中CIN的治疗策略的发展产生重大影响。这项研究旨在评估来自10例腔BBC患者的肿瘤组织样本中的CIN和CH，并将其与已建立的临床病理参数进行比较。这项研究的结果表明，管腔BBC患者表现出中间CIN和稳定的非整倍体，两者都与淋巴管浸润有关。我们的结果还提供了有价值的初步数据，这些数据可能有助于理解CIN和CH在BC风险分层和未来治疗策略发展中的意义。
