PDF(Pubmed)
Abstract：
Functional neurological disorder (FND), formerly called conversion disorder, is a condition characterized by neurological symptoms that lack an identifiable organic purpose. These signs, which can consist of motor, sensory, or cognitive disturbances, are not deliberately produced and often vary in severity. Its diagnosis is predicated on clinical evaluation and the exclusion of other medical or psychiatric situations. Its treatment typically involves a multidisciplinary technique addressing each of the neurological symptoms and underlying psychological factors via a mixture of medical management, psychotherapy, and supportive interventions. Recent advances in neuroimaging and a deeper exploration of its epidemiology, pathophysiology, and clinical presentation have shed new light on this disorder. This paper synthesizes the current knowledge on FND, focusing on its epidemiology and underlying mechanisms, neuroimaging insights, and the differentiation of FND from feigning or malingering. This review highlights the phenotypic heterogeneity of FND and the diagnostic challenges it presents. It also discusses the significant role of neuroimaging in unraveling the complex neural underpinnings of FND and its potential in predicting treatment response. This paper underscores the importance of a nuanced understanding of FND in informing clinical practice and guiding future research. With advancements in neuroimaging techniques and growing recognition of the disorder\'s multifaceted nature, the paper suggests a promising trajectory toward more effective, personalized treatment strategies and a better overall understanding of the disorder.
摘要：
功能性神经疾病（FND），以前称为转换障碍，是一种以神经症状为特征的疾病，缺乏可识别的有机目的。这些迹象,它可以由电机组成，感官,或者认知障碍，不是故意生产的，而且严重程度往往各不相同。其诊断基于临床评估和排除其他医学或精神病情况。它的治疗通常涉及一种多学科技术，通过混合的医疗管理来解决每种神经症状和潜在的心理因素。心理治疗,和支持性干预措施。神经影像学的最新进展及其流行病学的更深入探索，病理生理学,和临床表现为这种疾病提供了新的思路。本文综合了当前有关FND的知识，关注其流行病学和潜在机制，神经成像见解，以及FND与假装或恶意的区别。这篇综述强调了FND的表型异质性及其提出的诊断挑战。它还讨论了神经影像学在揭示FND复杂神经基础中的重要作用及其在预测治疗反应中的潜力。本文强调了对FND的细致理解在指导临床实践和指导未来研究方面的重要性。随着神经成像技术的进步和对该疾病多面性的认识日益加深，这篇论文提出了一个有希望的轨迹，朝着更有效的方向发展，个性化的治疗策略和对疾病的更好的整体理解。
