新型脒衍生物 K1586 通过诱导 Chk1 不稳定性使结直肠癌细胞对电离辐射敏感。
关键词: Chk1 amidine-containing compound anticancer radiosensitizer replication stress
Mesh : Checkpoint Kinase 1 / metabolism antagonists & inhibitors Humans Colorectal Neoplasms / drug therapy metabolism pathology radiotherapy Amidines / pharmacology Cell Line, Tumor Radiation, Ionizing Radiation-Sensitizing Agents / pharmacology DNA Replication / drug effects Cell Proliferation / drug effects DNA Damage / drug effects Cell Cycle / drug effects
来 源:
DOI:10.3390/ijms25084396
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