PDF(Pubmed)
Abstract：
Background: Dental Anomaly Pattern (DAP) is a collection of morphologic, numeric, and eruptive anomalies of teeth that are often observed together, suggesting a potential genetic relationship. Our objective was to assess the potential associations of Molar-Incisor Hypomineralization (MIH), a common developmental defect of enamel mineralization with a controversial etiology, with two specific components of DAP: (1) agenesis (AG) and (2) infraoccluded deciduous molars (IODM). Establishing such an association between MIH and one or both anomalies would provide evidence supporting a genetic link between MIH and DAP. Methods: We examined pretreatment intraoral standardized photographies and panoramic radiographs from 574 children aged 8-14 years, 287 having MIH and 287 without MIH, comparing the frequencies of AG and IODM in both groups. The subject samples were sourced from the databases of the orthodontic department at a university hospital. Results: The frequencies of AG in the MIH and non-MIH groups were 7% and 8%, respectively (p = 0.751). The corresponding frequencies of IODM were 27% and 19.2%, respectively (p = 0.082). That is, children with MIH did not exhibit an increased frequency of AG or IODM compared to those without MIH. Conclusions: These findings do not support the inclusion of MIH in DAP. Nevertheless, further analysis of possible associations is necessary to definitively validate or invalidate this hypothesis.
摘要：
背景：牙科异常模式（DAP）是一个形态学的集合，数值,和经常一起观察到的牙齿喷发异常，暗示了潜在的遗传关系。我们的目的是评估磨牙切牙低矿化（MIH）的潜在关联，一种常见的牙釉质矿化发育缺陷，病因有争议，具有DAP的两个特定成分：（1）发育不全（AG）和（2）下颌落叶磨牙（IODM）。在MIH与一个或两个异常之间建立这种关联将提供支持MIH与DAP之间遗传联系的证据。方法：我们检查了574名8-14岁儿童的口腔内标准化照片和全景X射线照片，具有MIH的287和没有MIH的287，比较两组中AG和IODM的频率。受试者样品来自大学医院正畸科的数据库。结果:MIH组和非MIH组的AG频率分别为7%和8%,分别（p=0.751）。IODM的相应频率分别为27%和19.2%,分别（p=0.082）。也就是说,与没有MIH的儿童相比,患有MIH的儿童AG或IODM的频率没有增加.结论：这些发现不支持将MIH纳入DAP。然而，有必要对可能的关联进行进一步分析,以明确验证或使这一假设无效.
