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Abstract：
Background: Philadelphia-negative chronic myeloproliferative neoplasms are a group of clonal hematopoietic disorders including polycythemia vera, essential thrombocythemia, and primary myelofi-brosis. These neoplasms are characterized by an increased risk of thrombotic complications. Several studies have highlighted that the study of vessels of the retina offers the opportunity to visualize, in vivo, the damage to microcirculation that is common in various systemic pathologies. Methods: in our study, forty patients underwent an ophthalmological examination, using non-invasive imaging tech-niques, for analyses of their retinal vascularization. The objective was to correlate the findings ob-tained from this study of the retina with different markers of thrombotic risk, to demonstrate the usefulness of studying retinal vessels as a possible new prognostic biomarker of thrombotic risk in patients affected by Philadelphia-negative chronic myeloproliferative neoplasms. Results: retinal imaging demonstrated changes in the microcirculation, with a reduced vascular density of the deep and superficial capillary plexuses with respect to a normal group, and a correlation between retinal changes and blood parameters. Conclusions: additional research will allow us to determine whether retinal changes in individuals with chronic myeloproliferative neoplasms could be predictive of the development of thrombotic events in these subjects.
摘要：
背景：费城阴性慢性骨髓增殖性肿瘤是一组克隆性造血疾病，包括真性红细胞增多症，原发性血小板增多症,和原发性骨髓萎缩症。这些肿瘤的特征是血栓性并发症的风险增加。几项研究强调，视网膜血管的研究提供了可视化的机会，在体内，在各种全身病理中常见的对微循环的损害。方法：在我们的研究中，40名患者接受了眼科检查，使用非侵入性成像技术，分析他们的视网膜血管形成。目的是将从视网膜研究中获得的结果与血栓形成风险的不同标志物相关联。在费城阴性慢性骨髓增殖性肿瘤患者中，研究视网膜血管作为血栓形成风险的新的预后生物标志物的有用性。结果：视网膜成像显示微循环的变化，与正常组相比，深部和浅表毛细血管丛的血管密度降低，以及视网膜变化和血液参数之间的相关性。结论：其他研究将使我们能够确定患有慢性骨髓增殖性肿瘤的个体的视网膜变化是否可以预测这些受试者中血栓形成事件的发展。
