PDF(Pubmed)
Abstract：
Stereotactic needle biopsy (SNB) may be performed to collect tissue samples from lesions not amenable to open surgery. Integration of tractography, intraoperative imaging and fluorescence has been applied to reduce risk of complications and confirm the adequacy of bioptic specimens. Clinical and radiological data from patients who underwent stereotactic needle biopsy with the use of intraoperative CT, tractography and 5-aminolevulinic acid (5-ALA) fluorescence in a single Hospital were retrospectively reviewed to evaluate the accuracy and safety of the procedure. Seven patients were included in the study, and all the collected specimens showed red fluorescence. In six of them, the final histopathological diagnosis was grade 4 glioblastoma IDH-wt and in the other case it was Diffuse large B-Cell Lymphoma. The integration of tractography, intraoperative CT and 5-ALA as an intraoperative marker of diagnostic samples may be suggested in biopsies of suspect gliomas and lymphomas. The cost-effectiveness of the procedure should be evaluated in future studies.
摘要：
可以进行立体定向针吸活检(SNB)以从不适合进行开放手术的病变中收集组织样本。纤维束造影的整合，术中成像和荧光已被用于降低并发症的风险，并确认活检标本的充分性。使用术中CT进行立体定向穿刺活检的患者的临床和放射学数据，对一家医院的纤维束造影和5-氨基乙酰丙酸(5-ALA)荧光进行回顾性分析,以评估手术的准确性和安全性.该研究包括7名患者，所有采集的标本均显示红色荧光。其中六个，最终的组织病理学诊断为4级胶质母细胞瘤IDH-wt,另一例为弥漫性大B细胞淋巴瘤.纤维束造影的整合，术中CT和5-ALA作为诊断样本的术中标志物,可用于可疑神经胶质瘤和淋巴瘤的活检.该程序的成本效益应在未来的研究中进行评估。
