PDF(Pubmed)
Abstract：
Bladder dysfunction, particularly neurogenic detrusor overactivity (DO), poses a substantial challenge in multiple sclerosis (MS) patients, detrimentally impacting their quality of life (QoL). Conventional therapies often fall short, necessitating alternative approaches like posterior tibial nerve stimulation (PTNS) for effective management. This narrative review critically examines the application of PTNS in treating DO among MS patients, aiming to provide a comprehensive synthesis of its efficacy, underlying mechanisms, and clinical outcomes. By evaluating a spectrum of studies, including randomized controlled trials and long-term follow-up research, the review elucidates PTNS\'s role in enhancing bladder control and ameliorating symptoms of urgency and incontinence, thereby improving patient well-being. Despite its potential, the review acknowledges the limited scope of existing research specific to MS-induced neurogenic DO and calls for further investigation to optimize PTNS protocols and understand its long-term benefits. Highlighting PTNS\'s minimal invasiveness and favorable safety profile, the review advocates for its consideration as a viable third-line treatment option in MS-related bladder dysfunction management. Through this analysis, the review contributes to the broader narrative of seeking effective, patient-centered therapeutic strategies for MS-related complications, underscoring the importance of personalized care in improving patient outcomes.
摘要：
膀胱功能障碍,特别是神经性逼尿肌过度活动(DO)，对多发性硬化症（MS）患者构成重大挑战，对他们的生活质量(QoL)产生不利影响。传统的治疗方法往往不够，需要替代方法，例如胫骨后神经刺激（PTNS）以进行有效管理。这篇叙述性综述严格审查了PTNS在MS患者治疗DO中的应用，旨在提供其功效的全面综合，潜在机制，和临床结果。通过评估一系列研究，包括随机对照试验和长期随访研究，该综述阐明了PTNS在增强膀胱控制和改善尿急和尿失禁症状中的作用，从而改善患者的健康。尽管有潜力,该综述承认针对MS诱导的神经源性DO的现有研究范围有限,并呼吁进一步研究以优化PTNS方案并了解其长期益处.突出了PTNS的最小侵入性和良好的安全性，该综述主张将其作为MS相关膀胱功能障碍治疗中可行的三线治疗选择.通过这种分析,审查有助于寻求有效的更广泛的叙述，以患者为中心的MS相关并发症的治疗策略，强调个性化护理在改善患者预后中的重要性。
