PDF(Pubmed)
Abstract：
Pentachlorophenol (PCP) is a ubiquitous emerging persistent organic pollutant detected in the environment and foodstuffs. Despite the dietary intake of PCP being performed using surveillance data, the assessment does not consider the bioaccessibility and bioavailability of PCP. Pork, beef, pork liver, chicken and freshwater fish Ctenopharyngodon Idella-fortified by three levels of PCP were processed by RIVM and the Caco-2 cell model after steaming, boiling and pan-frying, and PCP in foods and digestive juices were detected using isotope dilution-UPLC-MS/MS. The culinary treatment and food matrix were significantly influenced (p < 0.05) in terms of the bioaccessibility and bioavailability of PCP. Pan-frying was a significant factor (p < 0.05) influencing the digestion and absorption of PCP in foods, with the following bioaccessibility: pork (81.37-90.36%), beef (72.09-83.63%), pork liver (69.11-78.07%), chicken (63.43-75.52%) and freshwater fish (60.27-72.14%). The bioavailability was as follows: pork (49.39-63.41%), beef (40.32-53.43%), pork liver (33.63-47.11%), chicken (30.63-40.83%) and freshwater fish (17.14-27.09%). Pork and beef with higher fat content were a key factor in facilitating the notable PCP bioaccessibility and bioavailability (p < 0.05). Further, the exposure of PCP to the population was significantly reduced by 42.70-98.46% after the consideration of bioaccessibility and bioavailability, with no potential health risk. It can improve the accuracy of risk assessment for PCP.
摘要：
五氯苯酚（PCP）是在环境和食品中检测到的一种无处不在的新兴持久性有机污染物。尽管使用监测数据进行PCP的饮食摄入，评估未考虑PCP的生物可利用性和生物利用度.猪肉,牛肉,猪肝,由三个水平的PCP强化的鸡和淡水鱼CtenopharyngodonIdella在蒸制后通过RIVM和Caco-2细胞模型进行处理，煮沸和煎炸，使用同位素稀释-UPLC-MS/MS检测食品和消化液中的PCP。就PCP的生物可及性和生物利用度而言，烹饪处理和食物基质受到显着影响（p<0.05）。煎炸是影响食品中PCP消化吸收的显著因素(p<0.05),具有以下生物可及性：猪肉(81.37-90.36%)，牛肉（72.09-83.63%），猪肝（69.11-78.07%），鸡(63.43-75.52%)和淡水鱼(60.27-72.14%)。生物利用度如下：猪肉（49.39-63.41%），牛肉（40.32-53.43%），猪肝(33.63-47.11%)，鸡(30.63-40.83%)和淡水鱼(17.14-27.09%)。脂肪含量较高的猪肉和牛肉是促进PCP生物可及性和生物利用度的关键因素(p<0.05)。Further,在考虑生物可及性和生物利用度后，PCP对人群的暴露显着减少了42.70-98.46％，没有潜在的健康风险。可以提高PCP风险评估的准确性。
